| http://purl.uniprot.org/citations/31982478 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31982478 | http://www.w3.org/2000/01/rdf-schema#comment | "In the mammalian ovary, the proteolysis of the extracellular matrix is dynamically regulated by plasminogen activator and plasminogen activator inhibitor (PAI), and it is a critical event that influences various physiological and pathological processes. Activin A is a member of the transforming growth factor-β superfamily and is expressed at a high level in human luteal cells that play an essential role in the regulation of the luteal function. At present, it is not known whether activin A can regulate the expression and production of PAI in human granulosa lutein (hGL) cells. The present study aimed to examine the effects of activin A on the expression and production of intraovarian PAI-1 and the underlying molecular mechanisms. Using primary and immortalized hGL cells as the cell model, we demonstrated that activin A upregulated the expression of PAI-1 and increased the production of PAI-1 in an autocrine/paracrine manner. Additionally, using a dual inhibition approach (molecular inhibitors and siRNA-mediated knockdown), we showed that this biological function is mediated by the ALK4-mediated SMAD3-SMAD4-dependent signaling pathway. Our findings suggest that activin A may be involved in the regulation of luteal function via the induction of PAI-1 expression and an increase in PAI-1 production."xsd:string |
| http://purl.uniprot.org/citations/31982478 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.mce.2020.110731"xsd:string |
| http://purl.uniprot.org/citations/31982478 | http://purl.uniprot.org/core/author | "Chen B."xsd:string |
| http://purl.uniprot.org/citations/31982478 | http://purl.uniprot.org/core/author | "Cao Y."xsd:string |
| http://purl.uniprot.org/citations/31982478 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/31982478 | http://purl.uniprot.org/core/author | "Leung P.C.K."xsd:string |
| http://purl.uniprot.org/citations/31982478 | http://purl.uniprot.org/core/author | "Chang H.M."xsd:string |
| http://purl.uniprot.org/citations/31982478 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/31982478 | http://purl.uniprot.org/core/name | "Mol Cell Endocrinol"xsd:string |
| http://purl.uniprot.org/citations/31982478 | http://purl.uniprot.org/core/pages | "110731"xsd:string |
| http://purl.uniprot.org/citations/31982478 | http://purl.uniprot.org/core/title | "ALK4-SMAD3/4 mediates the effects of activin A on the upregulation of PAI-1 in human granulosa lutein cells."xsd:string |
| http://purl.uniprot.org/citations/31982478 | http://purl.uniprot.org/core/volume | "505"xsd:string |
| http://purl.uniprot.org/citations/31982478 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31982478 |
| http://purl.uniprot.org/citations/31982478 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31982478 |
| http://purl.uniprot.org/uniprot/#_B6E5W7-mappedCitation-31982478 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31982478 |
| http://purl.uniprot.org/uniprot/#_P05111-mappedCitation-31982478 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31982478 |
| http://purl.uniprot.org/uniprot/#_P36896-mappedCitation-31982478 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31982478 |
| http://purl.uniprot.org/uniprot/P36896 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31982478 |
| http://purl.uniprot.org/uniprot/P05111 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31982478 |
| http://purl.uniprot.org/uniprot/B6E5W7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31982478 |