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| http://purl.uniprot.org/citations/31985401 | http://www.w3.org/2000/01/rdf-schema#comment | "LAR-type receptor phosphotyrosine-phosphatases (LAR-RPTPs) are presynaptic adhesion molecules that interact trans-synaptically with multitudinous postsynaptic adhesion molecules, including SliTrks, SALMs, and TrkC. Via these interactions, LAR-RPTPs are thought to function as synaptogenic wiring molecules that promote neural circuit formation by mediating the establishment of synapses. To test the synaptogenic functions of LAR-RPTPs, we conditionally deleted the genes encoding all three LAR-RPTPs, singly or in combination, in mice before synapse formation. Strikingly, deletion of LAR-RPTPs had no effect on synaptic connectivity in cultured neurons or in vivo, but impaired NMDA-receptor-mediated responses. Deletion of LAR-RPTPs decreased NMDA-receptor-mediated responses by a trans-synaptic mechanism. In cultured neurons, deletion of all LAR-RPTPs led to a reduction in synaptic NMDA-receptor EPSCs, without changing the subunit composition or the protein levels of NMDA-receptors. In vivo, deletion of all LAR-RPTPs in the hippocampus at birth also did not alter synaptic connectivity as measured via AMPA-receptor-mediated synaptic responses at Schaffer-collateral synapses monitored in juvenile mice, but again decreased NMDA-receptor mediated synaptic transmission. Thus, LAR-RPTPs are not essential for synapse formation, but control synapse properties by regulating postsynaptic NMDA-receptors via a trans-synaptic mechanism that likely involves binding to one or multiple postsynaptic ligands."xsd:string |
| http://purl.uniprot.org/citations/31985401 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.53406"xsd:string |
| http://purl.uniprot.org/citations/31985401 | http://purl.uniprot.org/core/author | "Sudhof T.C."xsd:string |
| http://purl.uniprot.org/citations/31985401 | http://purl.uniprot.org/core/author | "Sclip A."xsd:string |
| http://purl.uniprot.org/citations/31985401 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/31985401 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/31985401 | http://purl.uniprot.org/core/pages | "e53406"xsd:string |
| http://purl.uniprot.org/citations/31985401 | http://purl.uniprot.org/core/title | "LAR receptor phospho-tyrosine phosphatases regulate NMDA-receptor responses."xsd:string |
| http://purl.uniprot.org/citations/31985401 | http://purl.uniprot.org/core/volume | "9"xsd:string |
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