| http://purl.uniprot.org/citations/31987001 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31987001 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31987001 | http://www.w3.org/2000/01/rdf-schema#comment | "A mysterious outbreak of atypical pneumonia in late 2019 was traced to a seafood wholesale market in Wuhan of China. Within a few weeks, a novel coronavirus tentatively named as 2019 novel coronavirus (2019-nCoV) was announced by the World Health Organization. We performed bioinformatics analysis on a virus genome from a patient with 2019-nCoV infection and compared it with other related coronavirus genomes. Overall, the genome of 2019-nCoV has 89% nucleotide identity with bat SARS-like-CoVZXC21 and 82% with that of human SARS-CoV. The phylogenetic trees of their orf1a/b, Spike, Envelope, Membrane and Nucleoprotein also clustered closely with those of the bat, civet and human SARS coronaviruses. However, the external subdomain of Spike's receptor binding domain of 2019-nCoV shares only 40% amino acid identity with other SARS-related coronaviruses. Remarkably, its orf3b encodes a completely novel short protein. Furthermore, its new orf8 likely encodes a secreted protein with an alpha-helix, following with a beta-sheet(s) containing six strands. Learning from the roles of civet in SARS and camel in MERS, hunting for the animal source of 2019-nCoV and its more ancestral virus would be important for understanding the origin and evolution of this novel lineage B betacoronavirus. These findings provide the basis for starting further studies on the pathogenesis, and optimizing the design of diagnostic, antiviral and vaccination strategies for this emerging infection."xsd:string |
| http://purl.uniprot.org/citations/31987001 | http://purl.org/dc/terms/identifier | "doi:10.1080/22221751.2020.1719902"xsd:string |
| http://purl.uniprot.org/citations/31987001 | http://purl.org/dc/terms/identifier | "doi:10.1080/22221751.2020.1719902"xsd:string |
| http://purl.uniprot.org/citations/31987001 | http://purl.uniprot.org/core/author | "Yuan S."xsd:string |
| http://purl.uniprot.org/citations/31987001 | http://purl.uniprot.org/core/author | "Yuan S."xsd:string |
| http://purl.uniprot.org/citations/31987001 | http://purl.uniprot.org/core/author | "Zhu Z."xsd:string |
| http://purl.uniprot.org/citations/31987001 | http://purl.uniprot.org/core/author | "Zhu Z."xsd:string |
| http://purl.uniprot.org/citations/31987001 | http://purl.uniprot.org/core/author | "Yuen K.Y."xsd:string |
| http://purl.uniprot.org/citations/31987001 | http://purl.uniprot.org/core/author | "Yuen K.Y."xsd:string |
| http://purl.uniprot.org/citations/31987001 | http://purl.uniprot.org/core/author | "Chan J.F."xsd:string |
| http://purl.uniprot.org/citations/31987001 | http://purl.uniprot.org/core/author | "Chan J.F."xsd:string |
| http://purl.uniprot.org/citations/31987001 | http://purl.uniprot.org/core/author | "To K.K."xsd:string |
| http://purl.uniprot.org/citations/31987001 | http://purl.uniprot.org/core/author | "To K.K."xsd:string |
| http://purl.uniprot.org/citations/31987001 | http://purl.uniprot.org/core/author | "Chu H."xsd:string |
| http://purl.uniprot.org/citations/31987001 | http://purl.uniprot.org/core/author | "Chu H."xsd:string |
| http://purl.uniprot.org/citations/31987001 | http://purl.uniprot.org/core/author | "Kok K.H."xsd:string |
| http://purl.uniprot.org/citations/31987001 | http://purl.uniprot.org/core/author | "Kok K.H."xsd:string |
| http://purl.uniprot.org/citations/31987001 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/31987001 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/31987001 | http://purl.uniprot.org/core/name | "Emerg. Microbes Infect."xsd:string |
| http://purl.uniprot.org/citations/31987001 | http://purl.uniprot.org/core/name | "Emerg. Microbes Infect."xsd:string |
| http://purl.uniprot.org/citations/31987001 | http://purl.uniprot.org/core/pages | "221-236"xsd:string |
| http://purl.uniprot.org/citations/31987001 | http://purl.uniprot.org/core/pages | "221-236"xsd:string |