| http://purl.uniprot.org/citations/31991095 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31991095 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31991095 | http://www.w3.org/2000/01/rdf-schema#comment | "Here, we apply quantitative chemical proteomics and untargeted lipidomics to assign a polyunsaturated fatty acid (PUFA)-specific triacylglycerol (TAG) lipase activity for diacylglycerol lipase-beta (DAGLβ) in macrophages. We demonstrate that DAGLβ but not DAGLα is expressed and active in bone marrow-derived macrophages (BMDMs) as determined by activity-based protein profiling analysis of SILAC BMDMs. Genetic disruption of DAGLβ resulted in accumulation of cellular TAGs composed of PUFA but not saturated/low unsaturated fatty acid counterparts, which is recapitulated in wild-type macrophages treated with a DAGLβ-selective inhibitor. Biochemical assays with synthetic substrates confirm PUFA-TAGs as authentic DAGLβ substrates. In summary, our findings identify DAGLβ as a PUFA-specific TAG lipase in primary macrophages."xsd:string |
| http://purl.uniprot.org/citations/31991095 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.chembiol.2020.01.005"xsd:string |
| http://purl.uniprot.org/citations/31991095 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.chembiol.2020.01.005"xsd:string |
| http://purl.uniprot.org/citations/31991095 | http://purl.uniprot.org/core/author | "Shin M."xsd:string |
| http://purl.uniprot.org/citations/31991095 | http://purl.uniprot.org/core/author | "Shin M."xsd:string |
| http://purl.uniprot.org/citations/31991095 | http://purl.uniprot.org/core/author | "Hsu K.L."xsd:string |
| http://purl.uniprot.org/citations/31991095 | http://purl.uniprot.org/core/author | "Hsu K.L."xsd:string |
| http://purl.uniprot.org/citations/31991095 | http://purl.uniprot.org/core/author | "Ware T.B."xsd:string |
| http://purl.uniprot.org/citations/31991095 | http://purl.uniprot.org/core/author | "Ware T.B."xsd:string |
| http://purl.uniprot.org/citations/31991095 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/31991095 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/31991095 | http://purl.uniprot.org/core/name | "Cell Chem. Biol."xsd:string |
| http://purl.uniprot.org/citations/31991095 | http://purl.uniprot.org/core/name | "Cell Chem. Biol."xsd:string |
| http://purl.uniprot.org/citations/31991095 | http://purl.uniprot.org/core/title | "DAGL-Beta Functions as a PUFA-Specific Triacylglycerol Lipase in Macrophages."xsd:string |
| http://purl.uniprot.org/citations/31991095 | http://purl.uniprot.org/core/title | "DAGL-Beta Functions as a PUFA-Specific Triacylglycerol Lipase in Macrophages."xsd:string |
| http://purl.uniprot.org/citations/31991095 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31991095 |
| http://purl.uniprot.org/citations/31991095 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31991095 |
| http://purl.uniprot.org/citations/31991095 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31991095 |
| http://purl.uniprot.org/citations/31991095 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31991095 |
| http://purl.uniprot.org/uniprot/Q91WC9 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/31991095 |
| http://purl.uniprot.org/uniprot/Q91WC9#attribution-726F44C2F11BD590FE7EF25B630017E6 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/31991095 |
| http://purl.uniprot.org/uniprot/Q91WC9#attribution-7F990872C56175C11DA22E06A5CD6D1B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/31991095 |
| http://purl.uniprot.org/uniprot/Q91WC9#attribution-E8D73BAE73EF2559668F7FC6A5D3DB53 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/31991095 |