| http://purl.uniprot.org/citations/31994005 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31994005 | http://www.w3.org/2000/01/rdf-schema#comment | "Residence at high altitude (> 2500 m) has been associated with an increased frequency of preeclampsia. Pappalysin-2 (PAPP-A2) is an insulin-like growth factor binding protein-5 (IGFBP-5) protease that is elevated in preeclampsia, and up-regulated by hypoxia in placental explants. The relationships between PAPP-A2, altitude, and indices of uteroplacental ischemia are unknown. We aimed to evaluate the association of altitude, preeclampsia, and uterine artery flow or vascular resistance with PAPP-A2 levels. PAPP-A2, uterine artery diameter, volumetric blood flow, and pulsatility indices were measured longitudinally in normotensive Andean women residing at low or high altitudes in Bolivia and in a separate Andean high-altitude cohort with or without preeclampsia. PAPP-A2 levels increased with advancing gestation, with the rise tending to be greater at high compared to low altitude, and higher in early-onset preeclamptic compared to normotensive women at high altitude. Uterine artery blood flow was markedly lower and pulsatility index higher in early-onset preeclamptic normotensive women compared to normotensive women. PAPP-A2 was unrelated to uterine artery pulsatility index in normotensive women but positively correlated in the early-onset preeclampsia cases. We concluded that PAPP-A2 is elevated at high altitude and especially in cases of early-onset preeclampsia with Doppler indices of uteroplacental ischemia."xsd:string |
| http://purl.uniprot.org/citations/31994005 | http://purl.org/dc/terms/identifier | "doi:10.1007/s43032-019-00050-3"xsd:string |
| http://purl.uniprot.org/citations/31994005 | http://purl.uniprot.org/core/author | "Julian C.G."xsd:string |
| http://purl.uniprot.org/citations/31994005 | http://purl.uniprot.org/core/author | "Moore L.G."xsd:string |
| http://purl.uniprot.org/citations/31994005 | http://purl.uniprot.org/core/author | "Winn V.D."xsd:string |
| http://purl.uniprot.org/citations/31994005 | http://purl.uniprot.org/core/author | "Browne V.A."xsd:string |
| http://purl.uniprot.org/citations/31994005 | http://purl.uniprot.org/core/author | "Gumina D.L."xsd:string |
| http://purl.uniprot.org/citations/31994005 | http://purl.uniprot.org/core/author | "Kramer A.W."xsd:string |
| http://purl.uniprot.org/citations/31994005 | http://purl.uniprot.org/core/author | "Lamale-Smith L.M."xsd:string |
| http://purl.uniprot.org/citations/31994005 | http://purl.uniprot.org/core/author | "Toledo-Jaldin L."xsd:string |
| http://purl.uniprot.org/citations/31994005 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/31994005 | http://purl.uniprot.org/core/name | "Reprod Sci"xsd:string |
| http://purl.uniprot.org/citations/31994005 | http://purl.uniprot.org/core/pages | "529-536"xsd:string |
| http://purl.uniprot.org/citations/31994005 | http://purl.uniprot.org/core/title | "Uteroplacental Ischemia Is Associated with Increased PAPP-A2."xsd:string |
| http://purl.uniprot.org/citations/31994005 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/31994005 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31994005 |
| http://purl.uniprot.org/citations/31994005 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31994005 |
| http://purl.uniprot.org/uniprot/#_Q59FU0-mappedCitation-31994005 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31994005 |
| http://purl.uniprot.org/uniprot/#_Q9BXP8-mappedCitation-31994005 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31994005 |
| http://purl.uniprot.org/uniprot/Q9BXP8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31994005 |
| http://purl.uniprot.org/uniprot/Q59FU0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31994005 |