| http://purl.uniprot.org/citations/31999304 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31999304 | http://www.w3.org/2000/01/rdf-schema#comment | "Aberrant NLRP3 inflammasome activation contributes to the development of endotoxemia. The importance of negative regulation of NLRP3 inflammasomes remains poorly understood. Here, we show that the E3 ubiquitin ligase Cbl-b is essential for preventing endotoxemia induced by a sub-lethal dose of LPS via a caspase-11/NLRP3-dependent manner. Further studies show that NLRP3 undergoes both K63- and K48-linked polyubiquitination. Cbl-b binds to the K63-ubiquitin chains attached to the NLRP3 leucine-rich repeat domain (LRR) via its ubiquitin-associated region (UBA) and then targets NLRP3 at K496 for K48-linked ubiquitination and proteasome-mediated degradation. We also identify RNF125 as an additional E3 ubiquitin ligase that initiates K63-linked ubiquitination of the NLRP3 LRR domain. Therefore, NLRP3 is sequentially ubiquitinated by K63- and K48-linked ubiquitination, thus keeping the NLRP3 inflammasomes in check and restraining endotoxemia."xsd:string |
| http://purl.uniprot.org/citations/31999304 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20182091"xsd:string |
| http://purl.uniprot.org/citations/31999304 | http://purl.uniprot.org/core/author | "Huang L."xsd:string |
| http://purl.uniprot.org/citations/31999304 | http://purl.uniprot.org/core/author | "Liu Q."xsd:string |
| http://purl.uniprot.org/citations/31999304 | http://purl.uniprot.org/core/author | "Guo H."xsd:string |
| http://purl.uniprot.org/citations/31999304 | http://purl.uniprot.org/core/author | "Tao L."xsd:string |
| http://purl.uniprot.org/citations/31999304 | http://purl.uniprot.org/core/author | "Xiao Y."xsd:string |
| http://purl.uniprot.org/citations/31999304 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/31999304 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/31999304 | http://purl.uniprot.org/core/author | "Tang J."xsd:string |
| http://purl.uniprot.org/citations/31999304 | http://purl.uniprot.org/core/author | "Langdon W.Y."xsd:string |
| http://purl.uniprot.org/citations/31999304 | http://purl.uniprot.org/core/author | "Yan C."xsd:string |
| http://purl.uniprot.org/citations/31999304 | http://purl.uniprot.org/core/author | "Wozniak D.J."xsd:string |
| http://purl.uniprot.org/citations/31999304 | http://purl.uniprot.org/core/author | "Lin G."xsd:string |
| http://purl.uniprot.org/citations/31999304 | http://purl.uniprot.org/core/author | "Gunn J.S."xsd:string |
| http://purl.uniprot.org/citations/31999304 | http://purl.uniprot.org/core/author | "Tang N."xsd:string |
| http://purl.uniprot.org/citations/31999304 | http://purl.uniprot.org/core/author | "Tu S."xsd:string |
| http://purl.uniprot.org/citations/31999304 | http://purl.uniprot.org/core/author | "Ahmer B.M."xsd:string |
| http://purl.uniprot.org/citations/31999304 | http://purl.uniprot.org/core/author | "Pope R.M."xsd:string |
| http://purl.uniprot.org/citations/31999304 | http://purl.uniprot.org/core/author | "Coppola V."xsd:string |
| http://purl.uniprot.org/citations/31999304 | http://purl.uniprot.org/core/author | "Lipkowitz S."xsd:string |
| http://purl.uniprot.org/citations/31999304 | http://purl.uniprot.org/core/author | "Amer A.O."xsd:string |
| http://purl.uniprot.org/citations/31999304 | http://purl.uniprot.org/core/author | "Torrelles J.B."xsd:string |
| http://purl.uniprot.org/citations/31999304 | http://purl.uniprot.org/core/author | "Rajaram M.V.S."xsd:string |