| http://purl.uniprot.org/citations/32005704 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32005704 | http://www.w3.org/2000/01/rdf-schema#comment | "The host environment is a crucial factor for considering the transplant of stem cell-derived immature pancreatic cells in patients with type 1 diabetes. Here, we investigated the effect of insulin (INS)-deficient diabetes on the fate of immature pancreatic endocrine cell grafts and the underlying mechanisms. Human induced pluripotent stem cell-derived pancreatic endocrine progenitor cells (EPCs), which contained a high proportion of chromogranin A+ NK6 homeobox 1+ cells and very few INS+ cells, were used. When the EPCs were implanted under the kidney capsule in immunodeficient mice, INS-deficient diabetes accelerated increase in plasma human C-peptide, a marker of graft-derived INS secretion. The acceleration was suppressed by INS infusion but not affected by partial attenuation of hyperglycemia by dapagliflozin, an INS-independent glucose-lowering agent. Immunohistochemical analyses indicated that the grafts from diabetic mice contained more endocrine cells including proliferative INS-producing cells compared with that from nondiabetic mice, despite no difference in whole graft mass between the two groups. These data suggest that INS-deficient diabetes upregulates the INS-secreting capacity of EPC grafts by increasing the number of endocrine cells including INS-producing cells without changing the graft mass. These findings provide useful insights into postoperative diabetic care for cell therapy using stem cell-derived pancreatic cells."xsd:string |
| http://purl.uniprot.org/citations/32005704 | http://purl.org/dc/terms/identifier | "doi:10.2337/db19-0728"xsd:string |
| http://purl.uniprot.org/citations/32005704 | http://purl.uniprot.org/core/author | "Toyoda T."xsd:string |
| http://purl.uniprot.org/citations/32005704 | http://purl.uniprot.org/core/author | "Ueno H."xsd:string |
| http://purl.uniprot.org/citations/32005704 | http://purl.uniprot.org/core/author | "Matsumoto H."xsd:string |
| http://purl.uniprot.org/citations/32005704 | http://purl.uniprot.org/core/author | "Ito R."xsd:string |
| http://purl.uniprot.org/citations/32005704 | http://purl.uniprot.org/core/author | "Hiyoshi H."xsd:string |
| http://purl.uniprot.org/citations/32005704 | http://purl.uniprot.org/core/author | "Mochida T."xsd:string |
| http://purl.uniprot.org/citations/32005704 | http://purl.uniprot.org/core/author | "Tsubooka-Yamazoe N."xsd:string |
| http://purl.uniprot.org/citations/32005704 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32005704 | http://purl.uniprot.org/core/name | "Diabetes"xsd:string |
| http://purl.uniprot.org/citations/32005704 | http://purl.uniprot.org/core/pages | "634-646"xsd:string |
| http://purl.uniprot.org/citations/32005704 | http://purl.uniprot.org/core/title | "Insulin-Deficient Diabetic Condition Upregulates the Insulin-Secreting Capacity of Human Induced Pluripotent Stem Cell-Derived Pancreatic Endocrine Progenitor Cells After Implantation in Mice."xsd:string |
| http://purl.uniprot.org/citations/32005704 | http://purl.uniprot.org/core/volume | "69"xsd:string |
| http://purl.uniprot.org/citations/32005704 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32005704 |
| http://purl.uniprot.org/citations/32005704 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32005704 |
| http://purl.uniprot.org/uniprot/#_D3Z595-mappedCitation-32005704 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32005704 |
| http://purl.uniprot.org/uniprot/#_D3Z596-mappedCitation-32005704 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32005704 |
| http://purl.uniprot.org/uniprot/#_E0CXX7-mappedCitation-32005704 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32005704 |
| http://purl.uniprot.org/uniprot/#_D3YWU5-mappedCitation-32005704 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32005704 |
| http://purl.uniprot.org/uniprot/#_D0EY27-mappedCitation-32005704 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32005704 |
| http://purl.uniprot.org/uniprot/#_P01326-mappedCitation-32005704 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32005704 |
| http://purl.uniprot.org/uniprot/#_Q5EEX1-mappedCitation-32005704 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32005704 |
| http://purl.uniprot.org/uniprot/#_P97313-mappedCitation-32005704 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32005704 |