| http://purl.uniprot.org/citations/32009482 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32009482 | http://www.w3.org/2000/01/rdf-schema#comment | "Purpose: It is suggested that tumour markers carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) could be used to predict the stage of pancreatic cancer. However, optimal cut-off values for CEA and CA19-9 are disputable. This study aimed to assess the value of CEA and CA19-9 serum levels at diagnosis of pancreatic ductal adenocarcinoma (PDAC) as predictors for the advanced stage of PDAC in patients discussed at pancreatic multidisciplinary team (MDT) meetings.Methods: Patients with suspected PDAC discussed at MDT meetings from 2013 to 2017 were reviewed, in order to determine optimal cut-off values of both CEA and CA19-9.Results: In total, 375 patients were included. Optimal cut-off values for predicting advanced PDAC were 7.0 ng/ml for CEA and 305.0 U/ml for CA19-9, resulting in positive predictive values of 83.3%, 73.6%, and 91.4% for CEA, CA19-9 and combined, respectively. Both tumour markers were independent predictors of advanced PDAC, demonstrated by an odds ratio of 4.21 (95% CI:1.85-9.56; p = 0.001) for CEA and 2.58 for CA19-9 (95% CI:1.30-5.14; p = 0.007).Conclusions: CEA appears to be a more robust predictor of advanced PDAC than CA19-9. Implementing CEA and CA19-9 serum levels during MDT meetings as an additional tool for establishing tumour resectability is worthwhile for tailored diagnostics."xsd:string |
| http://purl.uniprot.org/citations/32009482 | http://purl.org/dc/terms/identifier | "doi:10.1080/1354750x.2020.1725786"xsd:string |
| http://purl.uniprot.org/citations/32009482 | http://purl.uniprot.org/core/author | "Swijnenburg R.J."xsd:string |
| http://purl.uniprot.org/citations/32009482 | http://purl.uniprot.org/core/author | "Putter H."xsd:string |
| http://purl.uniprot.org/citations/32009482 | http://purl.uniprot.org/core/author | "Bonsing B.A."xsd:string |
| http://purl.uniprot.org/citations/32009482 | http://purl.uniprot.org/core/author | "Vahrmeijer A.L."xsd:string |
| http://purl.uniprot.org/citations/32009482 | http://purl.uniprot.org/core/author | "Groen J.V."xsd:string |
| http://purl.uniprot.org/citations/32009482 | http://purl.uniprot.org/core/author | "Mieog J.S.D."xsd:string |
| http://purl.uniprot.org/citations/32009482 | http://purl.uniprot.org/core/author | "van Manen L."xsd:string |
| http://purl.uniprot.org/citations/32009482 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32009482 | http://purl.uniprot.org/core/name | "Biomarkers"xsd:string |
| http://purl.uniprot.org/citations/32009482 | http://purl.uniprot.org/core/pages | "186-193"xsd:string |
| http://purl.uniprot.org/citations/32009482 | http://purl.uniprot.org/core/title | "Elevated CEA and CA19-9 serum levels independently predict advanced pancreatic cancer at diagnosis."xsd:string |
| http://purl.uniprot.org/citations/32009482 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/32009482 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32009482 |
| http://purl.uniprot.org/citations/32009482 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32009482 |
| http://purl.uniprot.org/uniprot/#_A0A024R0K5-mappedCitation-32009482 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32009482 |
| http://purl.uniprot.org/uniprot/#_Q13984-mappedCitation-32009482 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32009482 |
| http://purl.uniprot.org/uniprot/#_Q14081-mappedCitation-32009482 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32009482 |
| http://purl.uniprot.org/uniprot/#_Q8N4D0-mappedCitation-32009482 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32009482 |
| http://purl.uniprot.org/uniprot/#_P06731-mappedCitation-32009482 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32009482 |
| http://purl.uniprot.org/uniprot/#_P78448-mappedCitation-32009482 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32009482 |
| http://purl.uniprot.org/uniprot/#_Q53G30-mappedCitation-32009482 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32009482 |
| http://purl.uniprot.org/uniprot/#_Q7KZ28-mappedCitation-32009482 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32009482 |