| http://purl.uniprot.org/citations/32012249 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32012249 | http://www.w3.org/2000/01/rdf-schema#comment | "Extracorporeal photochemotherapy (ECP) that takes advantage of the immunomodulatory effects of UV light has been extensively used for many years for the treatment of several T cell-mediated diseases, including graft-versus-host disease (GvHD) and systemic scleroderma. Immune mechanisms that lead to the establishment of T cell tolerance in ECP-treated patients remain poorly known. In this study, we have tested the effect of UV/psoralen-treated BM-derived dendritic cells, referred to as ECP-BMDCs on the outcome of an antigen-specific T cell-mediated reaction, that is, contact hypersensitivity (CHS), which is mediated by CD8+ effector T cells (CD8+ Teff ). The intravenous (i.v.) injection of antigen-pulsed ECP-BMDCs in recipient C57BL/6 mice induced specific CD8+ T cells endowed with immunomodulatory properties (referred to as CD8+ TECP ), which prevented the priming of CD8+ Teff and the development of CHS, independently of conventional CD4+ regulatory T cells. CD8+ TECP mediated tolerance by inhibiting the migration and functions of skin DC and subsequently the priming of CD8+ Teff . CD8+ TECP displayed none of the phenotypes of the usual CD8+ T regulatory cells described so far. Our results reveal an underestimated participation of CD8+ T cells to ECP-induced immunomodulation that could explain the therapeutic effects of ECP in T cell-mediated diseases."xsd:string |
| http://purl.uniprot.org/citations/32012249 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.201948318"xsd:string |
| http://purl.uniprot.org/citations/32012249 | http://purl.uniprot.org/core/author | "Rigal D."xsd:string |
| http://purl.uniprot.org/citations/32012249 | http://purl.uniprot.org/core/author | "Griffith T.S."xsd:string |
| http://purl.uniprot.org/citations/32012249 | http://purl.uniprot.org/core/author | "Nicolas J.F."xsd:string |
| http://purl.uniprot.org/citations/32012249 | http://purl.uniprot.org/core/author | "Cognasse F."xsd:string |
| http://purl.uniprot.org/citations/32012249 | http://purl.uniprot.org/core/author | "Nosbaum A."xsd:string |
| http://purl.uniprot.org/citations/32012249 | http://purl.uniprot.org/core/author | "Vocanson M."xsd:string |
| http://purl.uniprot.org/citations/32012249 | http://purl.uniprot.org/core/author | "Hequet O."xsd:string |
| http://purl.uniprot.org/citations/32012249 | http://purl.uniprot.org/core/author | "Blasco E."xsd:string |
| http://purl.uniprot.org/citations/32012249 | http://purl.uniprot.org/core/author | "Guironnet-Paquet A."xsd:string |
| http://purl.uniprot.org/citations/32012249 | http://purl.uniprot.org/core/author | "Nicolas-Virelizier E."xsd:string |
| http://purl.uniprot.org/citations/32012249 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32012249 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/32012249 | http://purl.uniprot.org/core/pages | "725-735"xsd:string |
| http://purl.uniprot.org/citations/32012249 | http://purl.uniprot.org/core/title | "CD8+ T cells mediate ultraviolet A-induced immunomodulation in a model of extracorporeal photochemotherapy."xsd:string |
| http://purl.uniprot.org/citations/32012249 | http://purl.uniprot.org/core/volume | "50"xsd:string |
| http://purl.uniprot.org/citations/32012249 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32012249 |
| http://purl.uniprot.org/citations/32012249 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32012249 |
| http://purl.uniprot.org/uniprot/#_A0A0U5CJG6-mappedCitation-32012249 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32012249 |
| http://purl.uniprot.org/uniprot/#_A0A1D8M9B3-mappedCitation-32012249 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32012249 |
| http://purl.uniprot.org/uniprot/#_A0A7R8GUQ3-mappedCitation-32012249 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32012249 |
| http://purl.uniprot.org/uniprot/#_A0A494B9G5-mappedCitation-32012249 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32012249 |
| http://purl.uniprot.org/uniprot/#_A0A494B9U2-mappedCitation-32012249 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32012249 |