| http://purl.uniprot.org/citations/32014112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32014112 | http://www.w3.org/2000/01/rdf-schema#comment | "Cyclic AMP (cAMP) is involved in many biological processes but little is known regarding its role in shaping immunity. Here we show that cAMP-PKA-CREB signaling (a pattern recognition receptor [PRR]-independent mechanism) regulates conventional type-2 Dendritic Cells (cDC2s) in mice and reprograms their Th17-inducing properties via repression of IRF4 and KLF4, transcription factors essential for cDC2-mediated Th2 induction. In mice, genetic loss of IRF4 phenocopies the effects of cAMP on Th17 induction and restoration of IRF4 prevents the cAMP effect. Moreover, curdlan, a PRR-dependent microbial product, activates CREB and represses IRF4 and KLF4, resulting in a pro-Th17 phenotype of cDC2s. These in vitro and in vivo results define a novel signaling pathway by which cDC2s display plasticity and provide a new molecular basis for the classification of novel cDC2 and cDC17 subsets. The findings also reveal that repressing IRF4 and KLF4 pathway can be harnessed for immuno-regulation."xsd:string |
| http://purl.uniprot.org/citations/32014112 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.49416"xsd:string |
| http://purl.uniprot.org/citations/32014112 | http://purl.uniprot.org/core/author | "Kim J.H."xsd:string |
| http://purl.uniprot.org/citations/32014112 | http://purl.uniprot.org/core/author | "Lee J."xsd:string |
| http://purl.uniprot.org/citations/32014112 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/32014112 | http://purl.uniprot.org/core/author | "Yasuda K."xsd:string |
| http://purl.uniprot.org/citations/32014112 | http://purl.uniprot.org/core/author | "Raz E."xsd:string |
| http://purl.uniprot.org/citations/32014112 | http://purl.uniprot.org/core/author | "Insel P.A."xsd:string |
| http://purl.uniprot.org/citations/32014112 | http://purl.uniprot.org/core/author | "Chung Y.J."xsd:string |
| http://purl.uniprot.org/citations/32014112 | http://purl.uniprot.org/core/author | "Webster N.J."xsd:string |
| http://purl.uniprot.org/citations/32014112 | http://purl.uniprot.org/core/author | "Nurnberg B."xsd:string |
| http://purl.uniprot.org/citations/32014112 | http://purl.uniprot.org/core/author | "Broide D.H."xsd:string |
| http://purl.uniprot.org/citations/32014112 | http://purl.uniprot.org/core/author | "Corr M."xsd:string |
| http://purl.uniprot.org/citations/32014112 | http://purl.uniprot.org/core/author | "Tao A."xsd:string |
| http://purl.uniprot.org/citations/32014112 | http://purl.uniprot.org/core/author | "Rifkin I.R."xsd:string |
| http://purl.uniprot.org/citations/32014112 | http://purl.uniprot.org/core/author | "Sciammas R."xsd:string |
| http://purl.uniprot.org/citations/32014112 | http://purl.uniprot.org/core/author | "Mo J.H."xsd:string |
| http://purl.uniprot.org/citations/32014112 | http://purl.uniprot.org/core/author | "Gonzalez-Navajas J.M."xsd:string |
| http://purl.uniprot.org/citations/32014112 | http://purl.uniprot.org/core/author | "Herdman D.S."xsd:string |
| http://purl.uniprot.org/citations/32014112 | http://purl.uniprot.org/core/author | "Kook C.M."xsd:string |
| http://purl.uniprot.org/citations/32014112 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32014112 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/32014112 | http://purl.uniprot.org/core/pages | "e49416"xsd:string |
| http://purl.uniprot.org/citations/32014112 | http://purl.uniprot.org/core/title | "Inhibition of IRF4 in dendritic cells by PRR-independent and -dependent signals inhibit Th2 and promote Th17 responses."xsd:string |