| http://purl.uniprot.org/citations/32023456 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32023456 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32023456 | http://www.w3.org/2000/01/rdf-schema#comment | "ADP-ribosylation of proteins is crucial for fundamental cellular processes. Despite increasing examples of DNA ADP-ribosylation, the impact of this modification on DNA metabolism and cell physiology is unknown. Here, we show that the DarTG toxin-antitoxin system from enteropathogenic Escherichia coli (EPEC) catalyzes reversible ADP-ribosylation of single-stranded DNA (ssDNA). The DarT toxin recognizes specific sequence motifs. EPEC DarG abrogates DarT toxicity by two distinct mechanisms: removal of DNA ADP-ribose (ADPr) groups and DarT sequestration. Furthermore, we investigate how cells recognize and deal with DNA ADP-ribosylation. We demonstrate that DNA ADPr stalls replication and is perceived as DNA damage. Removal of ADPr from DNA requires the sequential activity of two DNA repair pathways, with RecF-mediated homologous recombination likely to transfer ADP-ribosylation from single-to double-stranded DNA (dsDNA) and subsequent nucleotide excision repair eliminating the lesion. Our work demonstrates that these DNA repair pathways prevent the genotoxic effects of DNA ADP-ribosylation."xsd:string |
| http://purl.uniprot.org/citations/32023456 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2020.01.014"xsd:string |
| http://purl.uniprot.org/citations/32023456 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2020.01.014"xsd:string |
| http://purl.uniprot.org/citations/32023456 | http://purl.uniprot.org/core/author | "Ahel I."xsd:string |
| http://purl.uniprot.org/citations/32023456 | http://purl.uniprot.org/core/author | "Ahel I."xsd:string |
| http://purl.uniprot.org/citations/32023456 | http://purl.uniprot.org/core/author | "Jankevicius G."xsd:string |
| http://purl.uniprot.org/citations/32023456 | http://purl.uniprot.org/core/author | "Jankevicius G."xsd:string |
| http://purl.uniprot.org/citations/32023456 | http://purl.uniprot.org/core/author | "Tang C.M."xsd:string |
| http://purl.uniprot.org/citations/32023456 | http://purl.uniprot.org/core/author | "Tang C.M."xsd:string |
| http://purl.uniprot.org/citations/32023456 | http://purl.uniprot.org/core/author | "Cooper C."xsd:string |
| http://purl.uniprot.org/citations/32023456 | http://purl.uniprot.org/core/author | "Cooper C."xsd:string |
| http://purl.uniprot.org/citations/32023456 | http://purl.uniprot.org/core/author | "Lawaree E."xsd:string |
| http://purl.uniprot.org/citations/32023456 | http://purl.uniprot.org/core/author | "Lawaree E."xsd:string |
| http://purl.uniprot.org/citations/32023456 | http://purl.uniprot.org/core/author | "Uphoff S."xsd:string |
| http://purl.uniprot.org/citations/32023456 | http://purl.uniprot.org/core/author | "Uphoff S."xsd:string |
| http://purl.uniprot.org/citations/32023456 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32023456 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32023456 | http://purl.uniprot.org/core/name | "Cell Rep."xsd:string |
| http://purl.uniprot.org/citations/32023456 | http://purl.uniprot.org/core/name | "Cell Rep."xsd:string |
| http://purl.uniprot.org/citations/32023456 | http://purl.uniprot.org/core/pages | "1373-1384"xsd:string |
| http://purl.uniprot.org/citations/32023456 | http://purl.uniprot.org/core/pages | "1373-1384"xsd:string |
| http://purl.uniprot.org/citations/32023456 | http://purl.uniprot.org/core/title | "DNA ADP-Ribosylation Stalls Replication and Is Reversed by RecF-Mediated Homologous Recombination and Nucleotide Excision Repair."xsd:string |
| http://purl.uniprot.org/citations/32023456 | http://purl.uniprot.org/core/title | "DNA ADP-Ribosylation Stalls Replication and Is Reversed by RecF-Mediated Homologous Recombination and Nucleotide Excision Repair."xsd:string |