| http://purl.uniprot.org/citations/32024701 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32024701 | http://www.w3.org/2000/01/rdf-schema#comment | "During thymic development, mouse γδ T cells commit to either an IFN-γ- or an IL-17-producing phenotype through mechanisms that remain unclear. In this study, we investigated the extent to which the SLAM/SAP signaling pathway regulates the functional programming of γδ T cells. Characterization of SLAM family receptor expression revealed that thymic γδ T cell subsets were each marked by distinct coexpression profiles of SLAMF1, SLAMF4, and SLAMF6. In the thymus, Vγ1 and Vγ4 T cells that exhibited an SLAMF1+SLAMF6+ double positive phenotype were largely contained within immature CD24+CD73- and CD24+CD73+ subsets, whereas SLAMF1 single positive, SLAMF6 single positive, or SLAMF1SLAMF6 double negative cells were found within mature CD24-CD73+ and CD24-CD73- subsets. In the periphery, SLAMF1 and SLAMF6 expression distinguished IL-17- and IFN-γ-producing γδ T cells, respectively. Disruption of SLAM family receptor signaling through deletion of SAP resulted in impaired thymic Vγ1 and Vγ4 T cell maturation at the CD24+CD73-SLAMF1+SLAMF6+ double positive stage that was associated with a decreased frequency of CD44+RORγt+ γδ T cells. Impaired development was in turn associated with decreased γδ T cell IL-17 and IFN-γ production in the thymus as well as in peripheral tissues. The role for SAP was subset-specific, as Vγ1Vδ6.3, Vγ4, Vγ5, but not Vγ6 subsets were SAP-dependent. Together, these data suggest that the SLAM/SAP signaling pathway plays a larger role in γδ T cell development than previously appreciated and represents a critical checkpoint in the functional programming of both IL-17- and IFN-γ-producing γδ T cell subsets."xsd:string |
| http://purl.uniprot.org/citations/32024701 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1901082"xsd:string |
| http://purl.uniprot.org/citations/32024701 | http://purl.uniprot.org/core/author | "Mei L."xsd:string |
| http://purl.uniprot.org/citations/32024701 | http://purl.uniprot.org/core/author | "Veillette A."xsd:string |
| http://purl.uniprot.org/citations/32024701 | http://purl.uniprot.org/core/author | "Boyson J.E."xsd:string |
| http://purl.uniprot.org/citations/32024701 | http://purl.uniprot.org/core/author | "Dragon J.A."xsd:string |
| http://purl.uniprot.org/citations/32024701 | http://purl.uniprot.org/core/author | "Dienz O."xsd:string |
| http://purl.uniprot.org/citations/32024701 | http://purl.uniprot.org/core/author | "DeVault V.L."xsd:string |
| http://purl.uniprot.org/citations/32024701 | http://purl.uniprot.org/core/author | "Krementsov D."xsd:string |
| http://purl.uniprot.org/citations/32024701 | http://purl.uniprot.org/core/author | "Baraev A."xsd:string |
| http://purl.uniprot.org/citations/32024701 | http://purl.uniprot.org/core/author | "Mistri S.K."xsd:string |
| http://purl.uniprot.org/citations/32024701 | http://purl.uniprot.org/core/author | "Musial S.C."xsd:string |
| http://purl.uniprot.org/citations/32024701 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32024701 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/32024701 | http://purl.uniprot.org/core/pages | "1521-1534"xsd:string |
| http://purl.uniprot.org/citations/32024701 | http://purl.uniprot.org/core/title | "Critical Role for SLAM/SAP Signaling in the Thymic Developmental Programming of IL-17- and IFN-gamma-Producing gammadelta T Cells."xsd:string |
| http://purl.uniprot.org/citations/32024701 | http://purl.uniprot.org/core/volume | "204"xsd:string |
| http://purl.uniprot.org/citations/32024701 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32024701 |
| http://purl.uniprot.org/citations/32024701 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32024701 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YY21-mappedCitation-32024701 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32024701 |
| http://purl.uniprot.org/uniprot/#_B2RWI0-mappedCitation-32024701 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32024701 |
| http://purl.uniprot.org/uniprot/#_Q18PG5-mappedCitation-32024701 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32024701 |
| http://purl.uniprot.org/uniprot/#_Q18PJ0-mappedCitation-32024701 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32024701 |
| http://purl.uniprot.org/uniprot/#_Q18PJ2-mappedCitation-32024701 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32024701 |