| http://purl.uniprot.org/citations/32027601 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32027601 | http://www.w3.org/2000/01/rdf-schema#comment | "Pituitary-directed medical treatment for Cushing's disease (CD) is currently represented by membrane receptor targeting drugs (somatostatin analogs and dopamine agonists). Somatostatin and dopamine receptors are regulated by β-arrestins, which have been shown to be differentially regulated by glucocorticoids in non-neuroendocrine cells. In this study we investigated the effects of glucocorticoids on β-arrestin expression in corticotroph tumor cells. First, AtT20 cells, a mouse model of CD, were exposed to dexamethasone (Dex) at different time points and β-arrestin expression was evaluated at mRNA and protein levels. Futhermore, β-arrestin mRNA expression was evaluated in 17 human corticotroph adenoma samples and correlated to patients' pre-operative cortisol levels. We observed that Dex treatment induced a time-dependent increase in β-arrestin 1 mRNA expression and a decrease in β-arrestin 2. The same modulation pattern was observed at protein level. Dex-mediated modulation of β-arrestins was abolished by co-treatment with mifepristone, and Dex withdrawal restored β-arrestin expression to basal levels after 72 h. The evaluation of β-arrestin mRNA in corticotroph adenomas from CD patients with variable disease activity showed a significant positive correlation between β-arrestin 1 mRNA and urinary cortisol levels. The effect of glucocorticoids on β-arrestin levels was confirmed by the analysis of two samples from a single patient, which underwent adenomectomy twice, with different pre-operative cortisol levels. In conclusion, glucocorticoids induce an inverse modulation of the two β-arrestin isofoms in corticotroph tumor cells. Since β-arrestins regulate membrane receptor functions, this finding may help to better understand the variable response to pituitary-targeting drugs in patients with Cushing's disease."xsd:string |
| http://purl.uniprot.org/citations/32027601 | http://purl.org/dc/terms/identifier | "doi:10.1530/joe-19-0311"xsd:string |
| http://purl.uniprot.org/citations/32027601 | http://purl.uniprot.org/core/author | "Feelders R.A."xsd:string |
| http://purl.uniprot.org/citations/32027601 | http://purl.uniprot.org/core/author | "Dogan F."xsd:string |
| http://purl.uniprot.org/citations/32027601 | http://purl.uniprot.org/core/author | "Ferone D."xsd:string |
| http://purl.uniprot.org/citations/32027601 | http://purl.uniprot.org/core/author | "Arvigo M."xsd:string |
| http://purl.uniprot.org/citations/32027601 | http://purl.uniprot.org/core/author | "Hofland L."xsd:string |
| http://purl.uniprot.org/citations/32027601 | http://purl.uniprot.org/core/author | "Lamberts S."xsd:string |
| http://purl.uniprot.org/citations/32027601 | http://purl.uniprot.org/core/author | "Gatto F."xsd:string |
| http://purl.uniprot.org/citations/32027601 | http://purl.uniprot.org/core/author | "van der Pas R."xsd:string |
| http://purl.uniprot.org/citations/32027601 | http://purl.uniprot.org/core/author | "Bruzzone E."xsd:string |
| http://purl.uniprot.org/citations/32027601 | http://purl.uniprot.org/core/author | "van Koetsveld P."xsd:string |
| http://purl.uniprot.org/citations/32027601 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32027601 | http://purl.uniprot.org/core/name | "J Endocrinol"xsd:string |
| http://purl.uniprot.org/citations/32027601 | http://purl.uniprot.org/core/pages | "101-113"xsd:string |
| http://purl.uniprot.org/citations/32027601 | http://purl.uniprot.org/core/title | "beta-arrestin expression in corticotroph tumor cells is modulated by glucocorticoids."xsd:string |
| http://purl.uniprot.org/citations/32027601 | http://purl.uniprot.org/core/volume | "245"xsd:string |
| http://purl.uniprot.org/citations/32027601 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32027601 |
| http://purl.uniprot.org/citations/32027601 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32027601 |
| http://purl.uniprot.org/uniprot/#_A8K103-mappedCitation-32027601 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32027601 |
| http://purl.uniprot.org/uniprot/#_B7Z1Q3-mappedCitation-32027601 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32027601 |
| http://purl.uniprot.org/uniprot/#_A8K4I6-mappedCitation-32027601 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32027601 |
| http://purl.uniprot.org/uniprot/#_K7ENA6-mappedCitation-32027601 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32027601 |
| http://purl.uniprot.org/uniprot/#_P32121-mappedCitation-32027601 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32027601 |