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Study objectives

To determine if nigrostriatal dopaminergic system function, evaluated by aromatic l-amino acid decarboxylase (AADC) activity using 6-[18F]fluoro-meta-tyrosine brain positron emission tomography (FMT-PET) can accurately and efficiently identify idiopathic rapid-eye-movement behavior disorder (IRBD) individuals at risk for conversion to a clinical diagnosis of Parkinson's disease (PD) or dementia with Lewy bodies (DLB).

Methods

We assessed prospectively striatal aromatic l-amino acid decarboxylase activity using FMT brain PET imaging in IRBD patients who were followed systematically every 1-3 months for 1-10 years. IRBD patients (n = 27) were enrolled in this prospective cohort study starting in 2009. Those who underwent follow-up scans between January 2011 and September 2014 (n = 24) were analyzed in the present study.

Results

Of the 24 IRBD patients with baseline and follow-up FMT-PET scans, 11 (45.8%) developed PD (n = 6) or DLB (n = 5). Compared to IRBD patients who were still disease-free, those who developed PD (n = 5) or DLB with parkinsonism (n = 1) had significantly reduced bilateral putaminal FMT uptake during the follow-up. Furthermore, the rate of FMT decline between baseline and follow-up scans was higher in all converted patients, even for those with DLB without parkinsonism, than in IRBD patients who remained disease-free.

Conclusions

FMT-PET, which represents a dynamic change in AADC activity over time, may also be a useful predictor for the risk of conversion to PD or DLB over short-term clinical follow-up periods, or when testing neuroprotective and restorative strategies in the prodromal phases of PD or DLB."xsd:string
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http://purl.uniprot.org/citations/32028226http://purl.uniprot.org/core/author"Miyamoto T."xsd:string
http://purl.uniprot.org/citations/32028226http://purl.uniprot.org/core/author"Sato T."xsd:string
http://purl.uniprot.org/citations/32028226http://purl.uniprot.org/core/author"Miyamoto M."xsd:string
http://purl.uniprot.org/citations/32028226http://purl.uniprot.org/core/author"Saitou J."xsd:string
http://purl.uniprot.org/citations/32028226http://purl.uniprot.org/core/date"2020"xsd:gYear
http://purl.uniprot.org/citations/32028226http://purl.uniprot.org/core/name"Sleep Med"xsd:string
http://purl.uniprot.org/citations/32028226http://purl.uniprot.org/core/pages"50-56"xsd:string
http://purl.uniprot.org/citations/32028226http://purl.uniprot.org/core/title"Longitudinal study of striatal aromatic l-amino acid decarboxylase activity in patients with idiopathic rapid eye movement sleep behavior disorder."xsd:string
http://purl.uniprot.org/citations/32028226http://purl.uniprot.org/core/volume"68"xsd:string
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