| http://purl.uniprot.org/citations/32032681 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32032681 | http://www.w3.org/2000/01/rdf-schema#comment | "Sendai virus V protein is a known antagonist of RIG-I-like receptors (RLRs) RIG-I and MDA5, which activate transcription factors IRF3, leading to activation of ISGF3 and NF-κB. These transcription factors are known activators of inducible NO synthase (iNOS) and increase the production of nitric oxide (NO). By inhibiting ISGF3 and NF-κB, the V protein acts as an indirect negative regulator of iNOS and NO. Here we report that the V gene knockout Sendai virus [SeV V(-)] markedly enhanced iNOS expression and subsequent NO production in infected macrophages compared to wild-type SeV. The knockout of RIG-I in cells inhibited SeV V(-)-induced iNOS expression and subsequent NO production. To understand the underlying mechanism of the V protein-mediated negative regulation of iNOS activation, we transfected HEK293T cells with RIG-I and the RIG-I regulatory protein TRIM25. Our results demonstrated that the V protein inhibited iNOS activation via the RIG-I/TRIM25 pathway. Moreover, the V protein inhibited TRIM25-mediated K63-linked ubiquitination of RIG-I, as well as its CARD-dependent interaction with mitochondrial antiviral signaling (MAVS) molecules. These results suggest that the V protein downregulates iNOS activation and inhibits NO production by preventing the RIG-I-MAVS interaction, possibly through its effect on the ubiquitination status of RIG-I."xsd:string |
| http://purl.uniprot.org/citations/32032681 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.micinf.2020.01.005"xsd:string |
| http://purl.uniprot.org/citations/32032681 | http://purl.uniprot.org/core/author | "Komatsu T."xsd:string |
| http://purl.uniprot.org/citations/32032681 | http://purl.uniprot.org/core/author | "Morita N."xsd:string |
| http://purl.uniprot.org/citations/32032681 | http://purl.uniprot.org/core/author | "Tanaka Y."xsd:string |
| http://purl.uniprot.org/citations/32032681 | http://purl.uniprot.org/core/author | "Naiki Y."xsd:string |
| http://purl.uniprot.org/citations/32032681 | http://purl.uniprot.org/core/author | "Koide N."xsd:string |
| http://purl.uniprot.org/citations/32032681 | http://purl.uniprot.org/core/author | "Odkhuu E."xsd:string |
| http://purl.uniprot.org/citations/32032681 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32032681 | http://purl.uniprot.org/core/name | "Microbes Infect"xsd:string |
| http://purl.uniprot.org/citations/32032681 | http://purl.uniprot.org/core/pages | "322-330"xsd:string |
| http://purl.uniprot.org/citations/32032681 | http://purl.uniprot.org/core/title | "Sendai virus V protein decreases nitric oxide production by inhibiting RIG-I signaling in infected RAW264.7 macrophages."xsd:string |
| http://purl.uniprot.org/citations/32032681 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/32032681 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32032681 |
| http://purl.uniprot.org/citations/32032681 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32032681 |
| http://purl.uniprot.org/uniprot/#_A1L0V6-mappedCitation-32032681 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32032681 |
| http://purl.uniprot.org/uniprot/#_A7YY79-mappedCitation-32032681 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32032681 |
| http://purl.uniprot.org/uniprot/#_Q05CC6-mappedCitation-32032681 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32032681 |
| http://purl.uniprot.org/uniprot/#_Q3KQQ7-mappedCitation-32032681 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32032681 |
| http://purl.uniprot.org/uniprot/#_Q3U1I9-mappedCitation-32032681 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32032681 |
| http://purl.uniprot.org/uniprot/#_Q6Q899-mappedCitation-32032681 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32032681 |
| http://purl.uniprot.org/uniprot/#_Q8C6Y8-mappedCitation-32032681 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32032681 |
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| http://purl.uniprot.org/uniprot/Q3U1I9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32032681 |