| http://purl.uniprot.org/citations/32040550 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32040550 | http://www.w3.org/2000/01/rdf-schema#comment | "c-Myc (Myc hereafter) is found to be deregulated and/or amplified in most acute myeloid leukemias (AMLs). Almost all AML cells are dependent upon Myc for their proliferation and survival. Thus, Myc has been proposed as a critical anti-AML target. Myc has Max-mediated transactivational and Myc-interacting zinc finger protein 1 (Miz1)-mediated transrepressional activities. The role of Myc-Max-mediated transactivation in the pathogenesis of AML has been well studied; however, the role of Myc-Miz1-mediated transrepression in AML is still somewhat obscure. Myc protein harboring a V394D mutation (MycV394D) is a mutant form of Myc that lacks transrepressional activity due to a defect in its ability to interact with Miz1. We found that, compared with Myc, the oncogenic function of MycV394D is significantly impaired. The AML/myeloproliferative disorder that develops in mice receiving MycV394D-transduced hematopoietic stem/progenitor cells (HSPCs) is significantly delayed compared with mice receiving Myc-transduced HSPCs. Using a murine MLL-AF9 AML model, we found that AML cells expressing MycV394D (intrinsic Myc deleted) are partially differentiated and show reductions in both colony-forming ability in vitro and leukemogenic capacity in vivo. The reduced frequency of leukemia stem cells (LSCs) among MycV394D-AML cells and their reduced leukemogenic capacity during serial transplantation suggest that Myc-Miz1 interaction is required for the self-renewal of LSCs. In addition, we found that MycV394D-AML cells are more sensitive to chemotherapy than are Myc-AML cells. Mechanistically, we found that Myc represses Miz1-mediated expression of CCAAT/enhancer-binding protein α (Cebpα) and Cebpδ, thus playing an important role in the pathogenesis of AML by maintaining the undifferentiated state and self-renewal capacity of LSCs."xsd:string |
| http://purl.uniprot.org/citations/32040550 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood.2019001863"xsd:string |
| http://purl.uniprot.org/citations/32040550 | http://purl.uniprot.org/core/author | "Hou Y."xsd:string |
| http://purl.uniprot.org/citations/32040550 | http://purl.uniprot.org/core/author | "Fu L."xsd:string |
| http://purl.uniprot.org/citations/32040550 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/32040550 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/32040550 | http://purl.uniprot.org/core/author | "Xu H."xsd:string |
| http://purl.uniprot.org/citations/32040550 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/32040550 | http://purl.uniprot.org/core/author | "Zhang F."xsd:string |
| http://purl.uniprot.org/citations/32040550 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/32040550 | http://purl.uniprot.org/core/author | "Xu Y."xsd:string |
| http://purl.uniprot.org/citations/32040550 | http://purl.uniprot.org/core/author | "Wei W."xsd:string |
| http://purl.uniprot.org/citations/32040550 | http://purl.uniprot.org/core/author | "Zhang J.'"xsd:string |
| http://purl.uniprot.org/citations/32040550 | http://purl.uniprot.org/core/author | "Dai S."xsd:string |
| http://purl.uniprot.org/citations/32040550 | http://purl.uniprot.org/core/author | "Joshi K."xsd:string |
| http://purl.uniprot.org/citations/32040550 | http://purl.uniprot.org/core/author | "Shao X."xsd:string |
| http://purl.uniprot.org/citations/32040550 | http://purl.uniprot.org/core/author | "Hao C."xsd:string |
| http://purl.uniprot.org/citations/32040550 | http://purl.uniprot.org/core/author | "Breslin P."xsd:string |
| http://purl.uniprot.org/citations/32040550 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32040550 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/32040550 | http://purl.uniprot.org/core/pages | "1133-1145"xsd:string |
| http://purl.uniprot.org/citations/32040550 | http://purl.uniprot.org/core/title | "Myc-Miz1 signaling promotes self-renewal of leukemia stem cells by repressing Cebpalpha and Cebpdelta."xsd:string |
| http://purl.uniprot.org/citations/32040550 | http://purl.uniprot.org/core/volume | "135"xsd:string |
| http://purl.uniprot.org/citations/32040550 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32040550 |