| http://purl.uniprot.org/citations/32041990 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32041990 | http://www.w3.org/2000/01/rdf-schema#comment | "Activation of the inflammasome is involved in the progression of retinal degenerative diseases, in particular, in the pathogenesis of Age-Related Macular Degeneration (AMD), with NLRP3 activation the focus of many investigations. In this study, we used genetic and pharmacological approaches to explore the role of the inflammasome in a mouse model of retinal degeneration. We identify that Casp1/11-/- mice have better-preserved retinal function, reduced inflammation and increased photoreceptor survivability. While Nlrp3-/- mice display some level of preservation of retinal function compared to controls, pharmacological inhibition of NLRP3 did not protect against photoreceptor cell death. Further, Aim2-/-, Nlrc4-/-, Asc-/-, and Casp11-/- mice show no substantial retinal protection. We propose that CASP-1-associated photoreceptor cell death occurs largely independently of NLRP3 and other established inflammasome sensor proteins, or that inhibition of a single sensor is not sufficient to repress the inflammatory cascade. Therapeutic targeting of CASP-1 may offer a more promising avenue to delay the progression of retinal degenerations."xsd:string |
| http://purl.uniprot.org/citations/32041990 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-020-58849-z"xsd:string |
| http://purl.uniprot.org/citations/32041990 | http://purl.uniprot.org/core/author | "Dietrich C."xsd:string |
| http://purl.uniprot.org/citations/32041990 | http://purl.uniprot.org/core/author | "Man S.M."xsd:string |
| http://purl.uniprot.org/citations/32041990 | http://purl.uniprot.org/core/author | "Doyle S.L."xsd:string |
| http://purl.uniprot.org/citations/32041990 | http://purl.uniprot.org/core/author | "Robertson A.A.B."xsd:string |
| http://purl.uniprot.org/citations/32041990 | http://purl.uniprot.org/core/author | "Fernando N."xsd:string |
| http://purl.uniprot.org/citations/32041990 | http://purl.uniprot.org/core/author | "Natoli R."xsd:string |
| http://purl.uniprot.org/citations/32041990 | http://purl.uniprot.org/core/author | "Chu-Tan J.A."xsd:string |
| http://purl.uniprot.org/citations/32041990 | http://purl.uniprot.org/core/author | "Aggio-Bruce R."xsd:string |
| http://purl.uniprot.org/citations/32041990 | http://purl.uniprot.org/core/author | "Wooff Y."xsd:string |
| http://purl.uniprot.org/citations/32041990 | http://purl.uniprot.org/core/author | "Wong J.H.C."xsd:string |
| http://purl.uniprot.org/citations/32041990 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32041990 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/32041990 | http://purl.uniprot.org/core/pages | "2263"xsd:string |
| http://purl.uniprot.org/citations/32041990 | http://purl.uniprot.org/core/title | "Caspase-1-dependent inflammasomes mediate photoreceptor cell death in photo-oxidative damage-induced retinal degeneration."xsd:string |
| http://purl.uniprot.org/citations/32041990 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/32041990 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32041990 |
| http://purl.uniprot.org/citations/32041990 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32041990 |
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| http://purl.uniprot.org/uniprot/#_A0A571BDI1-mappedCitation-32041990 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32041990 |
| http://purl.uniprot.org/uniprot/#_A0A3B2W7U6-mappedCitation-32041990 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32041990 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4EGE7-mappedCitation-32041990 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32041990 |
| http://purl.uniprot.org/uniprot/#_A0A571BF22-mappedCitation-32041990 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32041990 |