| http://purl.uniprot.org/citations/32044878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32044878 | http://www.w3.org/2000/01/rdf-schema#comment | "Gallbladder cancer (GBC) is a rare disease with high mortality. However, no biomarkers for the carcinogenesis, progression, prognosis, and early diagnosis are clinically available. This study investigated the expressions of cystathionine-β-synthase (CBS) and C-C chemokine receptor 7 (CCR7) protein and their clinical and pathologic significances in gallbladder squamous cell/adenosquamous carcinomas (SC/ASC) and adenocarcinomas (AC). CBS and chemokine ligand 21 (CCL21) expression was measured using immunohistochemistry in 69 SC/ASCs and 146 ACs. A significantly high percentage of patients with an age above 45 years, lymph node metastasis, and invasion was observed in the SCs/ASCs compared with ACs (P<0.05). Both AC and SC/ASC patients with positive CBS and CCL21 expression exhibited a high tumor-lymph node-metastasis stage, lymph node metastasis, and invasion compared with patients with negative CBS and CCL21 expression (P<0.05 or P<0.01). SC/ASC patients with positive CBS expression was prone to have a larger tumor size than those with negative expression (P<0.05). Positive CBS and CCL21 expression correlated with poor differentiation and larger tumor size in AC patients. Positive CBS and CCL21 are closely associated with a decreased overall survival in SC/ASC and AC patients (P<0.05 or P<0.01) and were independent factors for a poor-prognosis. Both CBS and CCL21 showed a good overall diagnostic performance for SC/ASC (AUC=0.742 and AUC=0.764, respectively) and AC (AUC=0.734 and AUC=0.718, respectively). In conclusion, positive CBS and CCL21 expression are closely associated with the clinical severity and poor prognosis in GBC, and can be a marker for the diagnosis of AC and SC/ASC type of GBC."xsd:string |
| http://purl.uniprot.org/citations/32044878 | http://purl.org/dc/terms/identifier | "doi:10.1097/pai.0000000000000705"xsd:string |
| http://purl.uniprot.org/citations/32044878 | http://purl.uniprot.org/core/author | "Liu Z."xsd:string |
| http://purl.uniprot.org/citations/32044878 | http://purl.uniprot.org/core/author | "Li D."xsd:string |
| http://purl.uniprot.org/citations/32044878 | http://purl.uniprot.org/core/author | "Yang Z."xsd:string |
| http://purl.uniprot.org/citations/32044878 | http://purl.uniprot.org/core/author | "Yuan Y."xsd:string |
| http://purl.uniprot.org/citations/32044878 | http://purl.uniprot.org/core/author | "Zou Q."xsd:string |
| http://purl.uniprot.org/citations/32044878 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32044878 | http://purl.uniprot.org/core/name | "Appl Immunohistochem Mol Morphol"xsd:string |
| http://purl.uniprot.org/citations/32044878 | http://purl.uniprot.org/core/pages | "103-110"xsd:string |
| http://purl.uniprot.org/citations/32044878 | http://purl.uniprot.org/core/title | "Clinical Significance of CBS and CCL21 in Gallbladder Adenocarcinomas and Squamous Cell/Adenosquamous Carcinomas."xsd:string |
| http://purl.uniprot.org/citations/32044878 | http://purl.uniprot.org/core/volume | "28"xsd:string |
| http://purl.uniprot.org/citations/32044878 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32044878 |
| http://purl.uniprot.org/citations/32044878 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32044878 |
| http://purl.uniprot.org/uniprot/#_B7Z2D6-mappedCitation-32044878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32044878 |
| http://purl.uniprot.org/uniprot/#_B7Z6W5-mappedCitation-32044878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32044878 |
| http://purl.uniprot.org/uniprot/#_Q3LR94-mappedCitation-32044878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32044878 |
| http://purl.uniprot.org/uniprot/#_O00585-mappedCitation-32044878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32044878 |
| http://purl.uniprot.org/uniprot/#_P35520-mappedCitation-32044878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32044878 |
| http://purl.uniprot.org/uniprot/#_Q5CCK7-mappedCitation-32044878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32044878 |
| http://purl.uniprot.org/uniprot/#_Q96EH7-mappedCitation-32044878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32044878 |
| http://purl.uniprot.org/uniprot/#_Q9NTF0-mappedCitation-32044878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32044878 |
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| http://purl.uniprot.org/uniprot/P35520 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32044878 |