| http://purl.uniprot.org/citations/32046974 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32046974 | http://www.w3.org/2000/01/rdf-schema#comment | "Post-stroke functional recovery can occur spontaneously during the subacute phase; however, how post-stroke fibrotic repair affects functional recovery is highly debated. Platelet-derived growth factor receptor β (PDGFRβ)-expressing pericytes are responsible for post-stroke fibrotic repair within infarct areas; therefore, we examined peri-infarct neural reorganization and functional recovery after permanent middle cerebral artery occlusion (pMCAO) using pericyte-deficient Pdgfrb+/- mice. Time-dependent reduction of infarct area sizes, i.e., repair, was significantly impaired in Pdgfrb+/- mice with recovery of cerebral blood flow (CBF) in ischemic areas attenuated by defective leptomeningeal arteriogenesis and intrainfarct angiogenesis. Peri-infarct astrogliosis, accompanied by increased STAT3 phosphorylation, was attenuated in Pdgfrb+/- mice. Pericyte-conditioned medium (PCM), particularly when treated with platelet-derived growth factor subunit B (PDGFB) homodimer (PDGF-BB; PCM/PDGF-BB), activated STAT3 and enhanced the proliferation and activity of cultured astrocytes. Although peri-infarct proliferation of oligodendrocyte (OL) precursor cells (OPCs) was induced promptly after pMCAO regardless of intrainfarct repair, OPC differentiation and remyelination were significantly attenuated in Pdgfrb+/- mice. Consistently, astrocyte-CM (ACM) promoted OPC differentiation and myelination, which were enhanced remarkably by adding PCM/PDGF-BB to the medium. Post-stroke functional recovery correlated well with the extent and process of intrainfarct repair and peri-infarct oligodendrogenesis. Overall, pericyte-mediated intrainfarct fibrotic repair through PDGFRβ may promote functional recovery through enhancement of peri-infarct oligodendrogenesis as well as astrogliosis after acute ischemic stroke."xsd:string |
| http://purl.uniprot.org/citations/32046974 | http://purl.org/dc/terms/identifier | "doi:10.1523/eneuro.0474-19.2020"xsd:string |
| http://purl.uniprot.org/citations/32046974 | http://purl.uniprot.org/core/author | "Nakamura K."xsd:string |
| http://purl.uniprot.org/citations/32046974 | http://purl.uniprot.org/core/author | "Shibahara T."xsd:string |
| http://purl.uniprot.org/citations/32046974 | http://purl.uniprot.org/core/author | "Yoshikawa Y."xsd:string |
| http://purl.uniprot.org/citations/32046974 | http://purl.uniprot.org/core/author | "Yamanaka K."xsd:string |
| http://purl.uniprot.org/citations/32046974 | http://purl.uniprot.org/core/author | "Tachibana M."xsd:string |
| http://purl.uniprot.org/citations/32046974 | http://purl.uniprot.org/core/author | "Kitazono T."xsd:string |
| http://purl.uniprot.org/citations/32046974 | http://purl.uniprot.org/core/author | "Komori M."xsd:string |
| http://purl.uniprot.org/citations/32046974 | http://purl.uniprot.org/core/author | "Wakisaka Y."xsd:string |
| http://purl.uniprot.org/citations/32046974 | http://purl.uniprot.org/core/author | "Ago T."xsd:string |
| http://purl.uniprot.org/citations/32046974 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32046974 | http://purl.uniprot.org/core/name | "eNeuro"xsd:string |
| http://purl.uniprot.org/citations/32046974 | http://purl.uniprot.org/core/pages | "ENEURO.0474-19.2020"xsd:string |
| http://purl.uniprot.org/citations/32046974 | http://purl.uniprot.org/core/title | "Pericyte-Mediated Tissue Repair through PDGFRbeta Promotes Peri-Infarct Astrogliosis, Oligodendrogenesis, and Functional Recovery after Acute Ischemic Stroke."xsd:string |
| http://purl.uniprot.org/citations/32046974 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/32046974 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32046974 |
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