| http://purl.uniprot.org/citations/32048423 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32048423 | http://www.w3.org/2000/01/rdf-schema#comment | "Identification of candidate genes associated with susceptibility of breast cancer can have a significant impact at a cancer management national healthcare systems level, making genetic testing more affordable and cost-effective. We have previously shown that the major histocompatibility complex class I-related chain A (MICA) was related to breast cancer and plays an important role in modulating immune response mechanisms through NKG2D receptor activation. Compared to our previous study, in this work, we recruited a new cohort composed of 354 unrelated Tunisian women affected by breast cancer and 380 age-matched women as controls, all genotyped for MICA-129 Met/Val (rs 1051792). Subsequently, we exanimated the distribution of this polymorphism in ten families. As a result, an association was found between the Val allele and Val/Val genotype and the risk of breast cancer (p = 2.5 × 10-15 ; OR = 2.40; p = 6.5 × 10-13 ; OR = 3.03, respectively). Stratified analysis with age and family history of cancer revealed an association between the Val/Val genotype and younger patients <40 years (p = .003; OR = 2.03). Among those patients having a family history of cancer, 68% had a Val/Val genotype (p = .02; OR = 1.82). In the family study, an analyse of pedigrees revealed that the majority of families showed the development of breast cancer at a young age. Moreover, all patients diagnosed with early-onset breast cancer had a Val/Val genotype. Our results lead us to propose that this polymorphism may be an inherited genetic biomarker contributing to an increased breast cancer risk in Tunisian women."xsd:string |
| http://purl.uniprot.org/citations/32048423 | http://purl.org/dc/terms/identifier | "doi:10.1111/iji.12480"xsd:string |
| http://purl.uniprot.org/citations/32048423 | http://purl.uniprot.org/core/author | "Tamouza R."xsd:string |
| http://purl.uniprot.org/citations/32048423 | http://purl.uniprot.org/core/author | "Guizani I."xsd:string |
| http://purl.uniprot.org/citations/32048423 | http://purl.uniprot.org/core/author | "Douik H."xsd:string |
| http://purl.uniprot.org/citations/32048423 | http://purl.uniprot.org/core/author | "Guemira F."xsd:string |
| http://purl.uniprot.org/citations/32048423 | http://purl.uniprot.org/core/author | "Ben Chaaben A."xsd:string |
| http://purl.uniprot.org/citations/32048423 | http://purl.uniprot.org/core/author | "Benammar-Elgaaied A."xsd:string |
| http://purl.uniprot.org/citations/32048423 | http://purl.uniprot.org/core/author | "Ayari F."xsd:string |
| http://purl.uniprot.org/citations/32048423 | http://purl.uniprot.org/core/author | "Ouni N."xsd:string |
| http://purl.uniprot.org/citations/32048423 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32048423 | http://purl.uniprot.org/core/name | "Int J Immunogenet"xsd:string |
| http://purl.uniprot.org/citations/32048423 | http://purl.uniprot.org/core/pages | "406-413"xsd:string |
| http://purl.uniprot.org/citations/32048423 | http://purl.uniprot.org/core/title | "MICA-129 Met/Val polymorphism could be a genetic biomarker for Familial Breast Cancer in the Tunisian population."xsd:string |
| http://purl.uniprot.org/citations/32048423 | http://purl.uniprot.org/core/volume | "47"xsd:string |
| http://purl.uniprot.org/citations/32048423 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32048423 |
| http://purl.uniprot.org/citations/32048423 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32048423 |
| http://purl.uniprot.org/uniprot/#_A0A0F6UUZ2-mappedCitation-32048423 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32048423 |
| http://purl.uniprot.org/uniprot/#_A0A0M3LB88-mappedCitation-32048423 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32048423 |
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| http://purl.uniprot.org/uniprot/#_A0A0M3LB98-mappedCitation-32048423 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32048423 |
| http://purl.uniprot.org/uniprot/#_A0A0M3LBA3-mappedCitation-32048423 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32048423 |
| http://purl.uniprot.org/uniprot/#_A0A0M3LBA6-mappedCitation-32048423 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32048423 |
| http://purl.uniprot.org/uniprot/#_A0A0M3LBB1-mappedCitation-32048423 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32048423 |