| http://purl.uniprot.org/citations/32049000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32049000 | http://www.w3.org/2000/01/rdf-schema#comment | "Health and survival in old age can be improved by changes in gene expression. RNA polymerase (Pol) I is the essential, conserved enzyme whose task is to generate the pre-ribosomal RNA (rRNA). We find that reducing the levels of Pol I activity is sufficient to extend lifespan in the fruit fly. This effect can be recapitulated by partial, adult-restricted inhibition, with both enterocytes and stem cells of the adult midgut emerging as important cell types. In stem cells, Pol I appears to act in the same longevity pathway as Pol III, implicating rRNA synthesis in these cells as the key lifespan determinant. Importantly, reduction in Pol I activity delays broad, age-related impairment and pathology, improving the function of diverse organ systems. Hence, our study shows that Pol I activity in the adult drives systemic, age-related decline in animal health and anticipates mortality."xsd:string |
| http://purl.uniprot.org/citations/32049000 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2020.01.017"xsd:string |
| http://purl.uniprot.org/citations/32049000 | http://purl.uniprot.org/core/author | "Li M."xsd:string |
| http://purl.uniprot.org/citations/32049000 | http://purl.uniprot.org/core/author | "Phillips G."xsd:string |
| http://purl.uniprot.org/citations/32049000 | http://purl.uniprot.org/core/author | "Alic N."xsd:string |
| http://purl.uniprot.org/citations/32049000 | http://purl.uniprot.org/core/author | "Filer D."xsd:string |
| http://purl.uniprot.org/citations/32049000 | http://purl.uniprot.org/core/author | "Broughton S.J."xsd:string |
| http://purl.uniprot.org/citations/32049000 | http://purl.uniprot.org/core/author | "Feseha Y."xsd:string |
| http://purl.uniprot.org/citations/32049000 | http://purl.uniprot.org/core/author | "Martinez Corrales G."xsd:string |
| http://purl.uniprot.org/citations/32049000 | http://purl.uniprot.org/core/author | "Rogan A."xsd:string |
| http://purl.uniprot.org/citations/32049000 | http://purl.uniprot.org/core/author | "Wenz K.C."xsd:string |
| http://purl.uniprot.org/citations/32049000 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32049000 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/32049000 | http://purl.uniprot.org/core/pages | "1661-1669.e4"xsd:string |
| http://purl.uniprot.org/citations/32049000 | http://purl.uniprot.org/core/title | "Partial Inhibition of RNA Polymerase I Promotes Animal Health and Longevity."xsd:string |
| http://purl.uniprot.org/citations/32049000 | http://purl.uniprot.org/core/volume | "30"xsd:string |
| http://purl.uniprot.org/citations/32049000 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32049000 |
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| http://purl.uniprot.org/uniprot/#_P91875-mappedCitation-32049000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32049000 |
| http://purl.uniprot.org/uniprot/#_Q9V9M6-mappedCitation-32049000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32049000 |
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| http://purl.uniprot.org/uniprot/#_Q9VD81-mappedCitation-32049000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32049000 |