| http://purl.uniprot.org/citations/32053105 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32053105 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32053105 | http://www.w3.org/2000/01/rdf-schema#comment | "The intracellular trafficking of growth factor receptors determines the activity of their downstream signaling pathways. Here, we show that the putative HSP-90 co-chaperone CHP-1 acts as a regulator of EGFR trafficking in C. elegans. Loss of chp-1 causes the retention of the EGFR in the ER and decreases MAPK signaling. CHP-1 is specifically required for EGFR trafficking, as the localization of other transmembrane receptors is unaltered in chp-1(lf) mutants, and the inhibition of hsp-90 or other co-chaperones does not affect EGFR localization. The role of the CHP-1 homolog CHORDC1 during EGFR trafficking is conserved in human cells. Analogous to C. elegans, the response of CHORDC1-deficient A431 cells to EGF stimulation is attenuated, the EGFR accumulates in the ER and ERK2 activity decreases. Although CHP-1 has been proposed to act as a co-chaperone for HSP90, our data indicate that CHP-1 plays an HSP90-independent function in controlling EGFR trafficking through the ER."xsd:string |
| http://purl.uniprot.org/citations/32053105 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.50986"xsd:string |
| http://purl.uniprot.org/citations/32053105 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.50986"xsd:string |
| http://purl.uniprot.org/citations/32053105 | http://purl.uniprot.org/core/author | "Hajnal A."xsd:string |
| http://purl.uniprot.org/citations/32053105 | http://purl.uniprot.org/core/author | "Hajnal A."xsd:string |
| http://purl.uniprot.org/citations/32053105 | http://purl.uniprot.org/core/author | "Walser M."xsd:string |
| http://purl.uniprot.org/citations/32053105 | http://purl.uniprot.org/core/author | "Walser M."xsd:string |
| http://purl.uniprot.org/citations/32053105 | http://purl.uniprot.org/core/author | "Haag A."xsd:string |
| http://purl.uniprot.org/citations/32053105 | http://purl.uniprot.org/core/author | "Haag A."xsd:string |
| http://purl.uniprot.org/citations/32053105 | http://purl.uniprot.org/core/author | "Henggeler A."xsd:string |
| http://purl.uniprot.org/citations/32053105 | http://purl.uniprot.org/core/author | "Henggeler A."xsd:string |
| http://purl.uniprot.org/citations/32053105 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32053105 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32053105 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/32053105 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/32053105 | http://purl.uniprot.org/core/title | "The CHORD protein CHP-1 regulates EGF receptor trafficking and signaling in C. elegans and in human cells."xsd:string |
| http://purl.uniprot.org/citations/32053105 | http://purl.uniprot.org/core/title | "The CHORD protein CHP-1 regulates EGF receptor trafficking and signaling in C. elegans and in human cells."xsd:string |
| http://purl.uniprot.org/citations/32053105 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/32053105 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/32053105 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32053105 |
| http://purl.uniprot.org/citations/32053105 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32053105 |
| http://purl.uniprot.org/citations/32053105 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32053105 |
| http://purl.uniprot.org/citations/32053105 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32053105 |