| http://purl.uniprot.org/citations/32059772 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32059772 | http://www.w3.org/2000/01/rdf-schema#comment | "The lung microvasculature is essential for gas exchange and commonly considered homogeneous. We show that VEGFA from the epithelium is required for a distinct endothelial cell (EC) population in the mouse lung. Vegfa is predominantly expressed by alveolar type 1 (AT1) cells and locally required to specify a subset of ECs. Single-cell RNA sequencing (scRNA-seq) reveals that ∼15% of lung ECs are transcriptionally distinct-marked by Carbonic anhydrase 4 (Car4)-and arise from bulk ECs, as suggested by trajectory analysis. Car4 ECs have extensive cellular projections and are separated from AT1 cells by a limited basement membrane without intervening pericytes. Car4 ECs are specifically lost upon epithelial Vegfa deletion; without Car4 ECs, the alveolar space is aberrantly enlarged despite the normal appearance of myofibroblasts. Lung Car4 ECs and retina tip ECs have common and distinct features. These findings support a signaling role of AT1 cells and shed light on alveologenesis."xsd:string |
| http://purl.uniprot.org/citations/32059772 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2020.01.009"xsd:string |
| http://purl.uniprot.org/citations/32059772 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/32059772 | http://purl.uniprot.org/core/author | "Zhou B."xsd:string |
| http://purl.uniprot.org/citations/32059772 | http://purl.uniprot.org/core/author | "Flodby P."xsd:string |
| http://purl.uniprot.org/citations/32059772 | http://purl.uniprot.org/core/author | "Borok Z."xsd:string |
| http://purl.uniprot.org/citations/32059772 | http://purl.uniprot.org/core/author | "Crandall E.D."xsd:string |
| http://purl.uniprot.org/citations/32059772 | http://purl.uniprot.org/core/author | "Ostrin E.J."xsd:string |
| http://purl.uniprot.org/citations/32059772 | http://purl.uniprot.org/core/author | "Wythe J.D."xsd:string |
| http://purl.uniprot.org/citations/32059772 | http://purl.uniprot.org/core/author | "Cain M.P."xsd:string |
| http://purl.uniprot.org/citations/32059772 | http://purl.uniprot.org/core/author | "Hutchison V."xsd:string |
| http://purl.uniprot.org/citations/32059772 | http://purl.uniprot.org/core/author | "Vila Ellis L."xsd:string |
| http://purl.uniprot.org/citations/32059772 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32059772 | http://purl.uniprot.org/core/name | "Dev Cell"xsd:string |
| http://purl.uniprot.org/citations/32059772 | http://purl.uniprot.org/core/pages | "617-630.e6"xsd:string |
| http://purl.uniprot.org/citations/32059772 | http://purl.uniprot.org/core/title | "Epithelial Vegfa Specifies a Distinct Endothelial Population in the Mouse Lung."xsd:string |
| http://purl.uniprot.org/citations/32059772 | http://purl.uniprot.org/core/volume | "52"xsd:string |
| http://purl.uniprot.org/citations/32059772 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32059772 |
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| http://purl.uniprot.org/uniprot/#_A0A2R8VHL2-mappedCitation-32059772 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32059772 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VI16-mappedCitation-32059772 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32059772 |