| http://purl.uniprot.org/citations/32060262 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32060262 | http://www.w3.org/2000/01/rdf-schema#comment | "Embryonal rhabdomyosarcoma (ERMS) is a childhood cancer that expresses myogenic master regulatory factor MYOD but fails to differentiate. Here, we show that the zinc finger transcription factor CASZ1 up-regulates MYOD signature genes and induces skeletal muscle differentiation in normal myoblasts and ERMS. The oncogenic activation of the RAS-MEK pathway suppresses CASZ1 expression in ERMS. ChIP-seq, ATAC-seq and RNA-seq experiments reveal that CASZ1 directly up-regulates skeletal muscle genes and represses non-muscle genes through affecting regional epigenetic modifications, chromatin accessibility and super-enhancer establishment. Next generation sequencing of primary RMS tumors identified a single nucleotide variant in the CASZ1 coding region that potentially contributes to ERMS tumorigenesis. Taken together, loss of CASZ1 activity, due to RAS-MEK signaling or genetic alteration, impairs ERMS differentiation, contributing to RMS tumorigenesis."xsd:string |
| http://purl.uniprot.org/citations/32060262 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-020-14684-4"xsd:string |
| http://purl.uniprot.org/citations/32060262 | http://purl.uniprot.org/core/author | "Liu Z."xsd:string |
| http://purl.uniprot.org/citations/32060262 | http://purl.uniprot.org/core/author | "Lei H."xsd:string |
| http://purl.uniprot.org/citations/32060262 | http://purl.uniprot.org/core/author | "Xu M."xsd:string |
| http://purl.uniprot.org/citations/32060262 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/32060262 | http://purl.uniprot.org/core/author | "Shern J.F."xsd:string |
| http://purl.uniprot.org/citations/32060262 | http://purl.uniprot.org/core/author | "Mendoza A."xsd:string |
| http://purl.uniprot.org/citations/32060262 | http://purl.uniprot.org/core/author | "Yohe M.E."xsd:string |
| http://purl.uniprot.org/citations/32060262 | http://purl.uniprot.org/core/author | "Carter S."xsd:string |
| http://purl.uniprot.org/citations/32060262 | http://purl.uniprot.org/core/author | "Lam N."xsd:string |
| http://purl.uniprot.org/citations/32060262 | http://purl.uniprot.org/core/author | "Thiele C.J."xsd:string |
| http://purl.uniprot.org/citations/32060262 | http://purl.uniprot.org/core/author | "Khan J."xsd:string |
| http://purl.uniprot.org/citations/32060262 | http://purl.uniprot.org/core/author | "Wei J.S."xsd:string |
| http://purl.uniprot.org/citations/32060262 | http://purl.uniprot.org/core/author | "Hernandez E.R."xsd:string |
| http://purl.uniprot.org/citations/32060262 | http://purl.uniprot.org/core/author | "Yockey O."xsd:string |
| http://purl.uniprot.org/citations/32060262 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32060262 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/32060262 | http://purl.uniprot.org/core/pages | "911"xsd:string |
| http://purl.uniprot.org/citations/32060262 | http://purl.uniprot.org/core/title | "CASZ1 induces skeletal muscle and rhabdomyosarcoma differentiation through a feed-forward loop with MYOD and MYOG."xsd:string |
| http://purl.uniprot.org/citations/32060262 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/32060262 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32060262 |
| http://purl.uniprot.org/citations/32060262 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32060262 |
| http://purl.uniprot.org/uniprot/#_A0A5F8MPC7-mappedCitation-32060262 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32060262 |