| http://purl.uniprot.org/citations/32064760 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32064760 | http://www.w3.org/2000/01/rdf-schema#comment | "KCC2, encoded in humans by the SLC12A5 gene, is a multifunctional neuron-specific protein initially identified as the chloride (Cl- ) extruder critical for hyperpolarizing GABAA receptor currents. Independently of its canonical function as a K-Cl cotransporter, KCC2 regulates the actin cytoskeleton via molecular interactions mediated through its large intracellular C-terminal domain (CTD). Contrary to the common assumption that embryonic neocortical projection neurons express KCC2 at non-significant levels, here we show that loss of KCC2 enhances apoptosis of late-born upper-layer cortical projection neurons in the embryonic brain. In utero electroporation of plasmids encoding truncated, transport-dead KCC2 constructs retaining the CTD was as efficient as of that encoding full-length KCC2 in preventing elimination of migrating projection neurons upon conditional deletion of KCC2. This was in contrast to the effect of a full-length KCC2 construct bearing a CTD missense mutation (KCC2R952H ), which disrupts cytoskeletal interactions and has been found in patients with neurological and psychiatric disorders, notably seizures and epilepsy. Together, our findings indicate ion transport-independent, CTD-mediated regulation of developmental apoptosis by KCC2 in migrating cortical projection neurons."xsd:string |
| http://purl.uniprot.org/citations/32064760 | http://purl.org/dc/terms/identifier | "doi:10.15252/embr.201948880"xsd:string |
| http://purl.uniprot.org/citations/32064760 | http://purl.uniprot.org/core/author | "Uvarov P."xsd:string |
| http://purl.uniprot.org/citations/32064760 | http://purl.uniprot.org/core/author | "Delpire E."xsd:string |
| http://purl.uniprot.org/citations/32064760 | http://purl.uniprot.org/core/author | "Kaila K."xsd:string |
| http://purl.uniprot.org/citations/32064760 | http://purl.uniprot.org/core/author | "Puskarjov M."xsd:string |
| http://purl.uniprot.org/citations/32064760 | http://purl.uniprot.org/core/author | "Vutskits L."xsd:string |
| http://purl.uniprot.org/citations/32064760 | http://purl.uniprot.org/core/author | "Mavrovic M."xsd:string |
| http://purl.uniprot.org/citations/32064760 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32064760 | http://purl.uniprot.org/core/name | "EMBO Rep"xsd:string |
| http://purl.uniprot.org/citations/32064760 | http://purl.uniprot.org/core/pages | "e48880"xsd:string |
| http://purl.uniprot.org/citations/32064760 | http://purl.uniprot.org/core/title | "Loss of non-canonical KCC2 functions promotes developmental apoptosis of cortical projection neurons."xsd:string |
| http://purl.uniprot.org/citations/32064760 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/32064760 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32064760 |
| http://purl.uniprot.org/citations/32064760 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32064760 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YU26-mappedCitation-32064760 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32064760 |
| http://purl.uniprot.org/uniprot/#_A0A076FR46-mappedCitation-32064760 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32064760 |
| http://purl.uniprot.org/uniprot/#_A0A076FRG6-mappedCitation-32064760 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32064760 |
| http://purl.uniprot.org/uniprot/#_A0A076FSX1-mappedCitation-32064760 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32064760 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J1E1-mappedCitation-32064760 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32064760 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YUW1-mappedCitation-32064760 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32064760 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YV84-mappedCitation-32064760 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32064760 |
| http://purl.uniprot.org/uniprot/#_A2AR81-mappedCitation-32064760 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32064760 |
| http://purl.uniprot.org/uniprot/#_A8K143-mappedCitation-32064760 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32064760 |