| http://purl.uniprot.org/citations/32066809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32066809 | http://www.w3.org/2000/01/rdf-schema#comment | "trans-Fatty acids (TFAs) are unsaturated fatty acids that contain one or more carbon-carbon double bonds in trans configuration. Epidemiological evidence has linked TFA consumption with various disorders, including cardiovascular diseases. However, the underlying pathological mechanisms are largely unknown. Here, we show a novel toxic mechanism of TFAs triggered by DNA damage. We found that elaidic acid (EA) and linoelaidic acid, major TFAs produced during industrial food manufacturing (so-called as industrial TFAs), but not their corresponding cis isomers, facilitated apoptosis induced by doxorubicin. Consistently, EA enhanced UV-induced embryonic lethality in C. elegans worms. The pro-apoptotic action of EA was blocked by knocking down Sab, a c-Jun N-terminal kinase (JNK)-interacting protein localizing at mitochondrial outer membrane, which mediates mutual amplification of mitochondrial reactive oxygen species (ROS) generation and JNK activation. EA enhanced doxorubicin-induced mitochondrial ROS generation and JNK activation, both of which were suppressed by Sab knockdown and pharmacological inhibition of either mitochondrial ROS generation, JNK, or Src-homology 2 domain-containing protein tyrosine phosphatase 1 (SHP1) as a Sab-associated protein. These results demonstrate that in response to DNA damage, TFAs drive the mitochondrial JNK-Sab-ROS positive feedback loop and ultimately apoptosis, which may provide insight into the common pathogenetic mechanisms of diverse TFA-related disorders."xsd:string |
| http://purl.uniprot.org/citations/32066809 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-020-59636-6"xsd:string |
| http://purl.uniprot.org/citations/32066809 | http://purl.uniprot.org/core/author | "Inoue A."xsd:string |
| http://purl.uniprot.org/citations/32066809 | http://purl.uniprot.org/core/author | "Suzuki S."xsd:string |
| http://purl.uniprot.org/citations/32066809 | http://purl.uniprot.org/core/author | "Takahashi M."xsd:string |
| http://purl.uniprot.org/citations/32066809 | http://purl.uniprot.org/core/author | "Hirata Y."xsd:string |
| http://purl.uniprot.org/citations/32066809 | http://purl.uniprot.org/core/author | "Matsuzawa A."xsd:string |
| http://purl.uniprot.org/citations/32066809 | http://purl.uniprot.org/core/author | "Noguchi T."xsd:string |
| http://purl.uniprot.org/citations/32066809 | http://purl.uniprot.org/core/author | "Matsui R."xsd:string |
| http://purl.uniprot.org/citations/32066809 | http://purl.uniprot.org/core/author | "Kono N."xsd:string |
| http://purl.uniprot.org/citations/32066809 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32066809 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/32066809 | http://purl.uniprot.org/core/pages | "2743"xsd:string |
| http://purl.uniprot.org/citations/32066809 | http://purl.uniprot.org/core/title | "trans-Fatty acids facilitate DNA damage-induced apoptosis through the mitochondrial JNK-Sab-ROS positive feedback loop."xsd:string |
| http://purl.uniprot.org/citations/32066809 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/32066809 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32066809 |
| http://purl.uniprot.org/citations/32066809 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32066809 |
| http://purl.uniprot.org/uniprot/#_B2R7Y8-mappedCitation-32066809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32066809 |
| http://purl.uniprot.org/uniprot/#_O60239-mappedCitation-32066809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32066809 |
| http://purl.uniprot.org/uniprot/#_Q6MZG3-mappedCitation-32066809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32066809 |
| http://purl.uniprot.org/uniprot/B2R7Y8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32066809 |
| http://purl.uniprot.org/uniprot/O60239 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32066809 |
| http://purl.uniprot.org/uniprot/Q6MZG3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32066809 |