| http://purl.uniprot.org/citations/32066949 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32066949 | http://www.w3.org/2000/01/rdf-schema#comment | "Differentiation of CD4+ T cells into either follicular helper T (TFH) or type 1 helper T (TH1) cells influences the balance between humoral and cellular adaptive immunity, but the mechanisms whereby pathogens elicit distinct effector cells are incompletely understood. Here we analyzed the spatiotemporal dynamics of CD4+ T cells during infection with recombinant vesicular stomatitis virus (VSV), which induces early, potent neutralizing antibodies, or recombinant lymphocytic choriomeningitis virus (LCMV), which induces a vigorous cellular response but inefficient neutralizing antibodies, expressing the same T cell epitope. Early exposure of dendritic cells to type I interferon (IFN), which occurred during infection with VSV, induced production of the cytokine IL-6 and drove TFH cell polarization, whereas late exposure to type I IFN, which occurred during infection with LCMV, did not induce IL-6 and allowed differentiation into TH1 cells. Thus, tight spatiotemporal regulation of type I IFN shapes antiviral CD4+ T cell differentiation and might instruct vaccine design strategies."xsd:string |
| http://purl.uniprot.org/citations/32066949 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41590-020-0596-6"xsd:string |
| http://purl.uniprot.org/citations/32066949 | http://purl.uniprot.org/core/author | "Fiore A."xsd:string |
| http://purl.uniprot.org/citations/32066949 | http://purl.uniprot.org/core/author | "Sala E."xsd:string |
| http://purl.uniprot.org/citations/32066949 | http://purl.uniprot.org/core/author | "Amit I."xsd:string |
| http://purl.uniprot.org/citations/32066949 | http://purl.uniprot.org/core/author | "De Giovanni M."xsd:string |
| http://purl.uniprot.org/citations/32066949 | http://purl.uniprot.org/core/author | "Kastenmuller W."xsd:string |
| http://purl.uniprot.org/citations/32066949 | http://purl.uniprot.org/core/author | "Kuka M."xsd:string |
| http://purl.uniprot.org/citations/32066949 | http://purl.uniprot.org/core/author | "Giustini L."xsd:string |
| http://purl.uniprot.org/citations/32066949 | http://purl.uniprot.org/core/author | "Bono E."xsd:string |
| http://purl.uniprot.org/citations/32066949 | http://purl.uniprot.org/core/author | "Iannacone M."xsd:string |
| http://purl.uniprot.org/citations/32066949 | http://purl.uniprot.org/core/author | "Medaglia C."xsd:string |
| http://purl.uniprot.org/citations/32066949 | http://purl.uniprot.org/core/author | "Giladi A."xsd:string |
| http://purl.uniprot.org/citations/32066949 | http://purl.uniprot.org/core/author | "Di Lucia P."xsd:string |
| http://purl.uniprot.org/citations/32066949 | http://purl.uniprot.org/core/author | "Eickhoff S."xsd:string |
| http://purl.uniprot.org/citations/32066949 | http://purl.uniprot.org/core/author | "Cristofani C."xsd:string |
| http://purl.uniprot.org/citations/32066949 | http://purl.uniprot.org/core/author | "Maganuco C.G."xsd:string |
| http://purl.uniprot.org/citations/32066949 | http://purl.uniprot.org/core/author | "Consolo E."xsd:string |
| http://purl.uniprot.org/citations/32066949 | http://purl.uniprot.org/core/author | "Cutillo V."xsd:string |
| http://purl.uniprot.org/citations/32066949 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32066949 | http://purl.uniprot.org/core/name | "Nat Immunol"xsd:string |
| http://purl.uniprot.org/citations/32066949 | http://purl.uniprot.org/core/pages | "321-330"xsd:string |
| http://purl.uniprot.org/citations/32066949 | http://purl.uniprot.org/core/title | "Spatiotemporal regulation of type I interferon expression determines the antiviral polarization of CD4+ T cells."xsd:string |
| http://purl.uniprot.org/citations/32066949 | http://purl.uniprot.org/core/volume | "21"xsd:string |