| http://purl.uniprot.org/citations/32078586 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32078586 | http://www.w3.org/2000/01/rdf-schema#comment | "Given the numerous health benefits of exercise, understanding how exercise capacity is regulated is a question of paramount importance. Circulating interleukin 6 (IL-6) levels surge during exercise and IL-6 favors exercise capacity. However, neither the cellular origin of circulating IL-6 during exercise nor the means by which this cytokine enhances exercise capacity has been formally established yet. Here we show through genetic means that the majority of circulating IL-6 detectable during exercise originates from muscle and that to increase exercise capacity, IL-6 must signal in osteoblasts to favor osteoclast differentiation and the release of bioactive osteocalcin in the general circulation. This explains why mice lacking the IL-6 receptor only in osteoblasts exhibit a deficit in exercise capacity of similar severity to the one seen in mice lacking muscle-derived IL-6 (mIL-6), and why this deficit is correctable by osteocalcin but not by IL-6. Furthermore, in agreement with the notion that IL-6 acts through osteocalcin, we demonstrate that mIL-6 promotes nutrient uptake and catabolism into myofibers during exercise in an osteocalcin-dependent manner. Finally, we show that the crosstalk between osteocalcin and IL-6 is conserved between rodents and humans. This study provides evidence that a muscle-bone-muscle endocrine axis is necessary to increase muscle function during exercise in rodents and humans."xsd:string |
| http://purl.uniprot.org/citations/32078586 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci133572"xsd:string |
| http://purl.uniprot.org/citations/32078586 | http://purl.uniprot.org/core/author | "Berger J.M."xsd:string |
| http://purl.uniprot.org/citations/32078586 | http://purl.uniprot.org/core/author | "Hidalgo J."xsd:string |
| http://purl.uniprot.org/citations/32078586 | http://purl.uniprot.org/core/author | "Chowdhury S."xsd:string |
| http://purl.uniprot.org/citations/32078586 | http://purl.uniprot.org/core/author | "Singh P."xsd:string |
| http://purl.uniprot.org/citations/32078586 | http://purl.uniprot.org/core/author | "Karsenty G."xsd:string |
| http://purl.uniprot.org/citations/32078586 | http://purl.uniprot.org/core/author | "Schulz L."xsd:string |
| http://purl.uniprot.org/citations/32078586 | http://purl.uniprot.org/core/author | "Ellingsgaard H."xsd:string |
| http://purl.uniprot.org/citations/32078586 | http://purl.uniprot.org/core/author | "Mera P."xsd:string |
| http://purl.uniprot.org/citations/32078586 | http://purl.uniprot.org/core/author | "Bruning J."xsd:string |
| http://purl.uniprot.org/citations/32078586 | http://purl.uniprot.org/core/author | "Yadav V.K."xsd:string |
| http://purl.uniprot.org/citations/32078586 | http://purl.uniprot.org/core/author | "Palmisano B."xsd:string |
| http://purl.uniprot.org/citations/32078586 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32078586 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/32078586 | http://purl.uniprot.org/core/pages | "2888-2902"xsd:string |
| http://purl.uniprot.org/citations/32078586 | http://purl.uniprot.org/core/title | "Muscle-derived interleukin 6 increases exercise capacity by signaling in osteoblasts."xsd:string |
| http://purl.uniprot.org/citations/32078586 | http://purl.uniprot.org/core/volume | "130"xsd:string |
| http://purl.uniprot.org/citations/32078586 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32078586 |
| http://purl.uniprot.org/citations/32078586 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32078586 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGF4-mappedCitation-32078586 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32078586 |
| http://purl.uniprot.org/uniprot/#_Q0PMN1-mappedCitation-32078586 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32078586 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JFG1-mappedCitation-32078586 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32078586 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JFT1-mappedCitation-32078586 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32078586 |