| http://purl.uniprot.org/citations/32080306 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32080306 | http://www.w3.org/2000/01/rdf-schema#comment | "The coordinated and sequential actions of lineage-specific transcription factors and epigenetic regulators are essential for the initiation and maintenance of cellular differentiation. We here report KDM4D histone demethylase as a key regulator of adipogenesis in C3H10T1/2 mesenchymal stem cells. The depletion of KDM4D results in impaired differentiation, which can be rescued by exogenous KDM4D, PPARγ, and C/EBPα, but not by C/EBPβ. In addition, KDM4D interacts physically and functionally with both NFIB and MLL1 complex to regulate C/EBPα and PPARγ expression upon adipogenic hormonal induction. Although KDM4D is dispensable for the binding of both NFIB and MLL1 complex to the target promoters, the demethylation of tri-methylated H3K9 by KDM4D is required for NFIB and MLL1 complex to deposit tri-methylated H3K4 and activate PPARγ and C/EBPα expression. Taken together, our data provide a molecular framework for lineage-specific transcription factor and histone modifiers to cooperate in adipogenic differentiation, in which KDM4D removes repressive histone marks at genes with a bivalent chromatin domain and allows NFIB and MLL1 complex to promote the expression of key adipogenic regulators."xsd:string |
| http://purl.uniprot.org/citations/32080306 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-020-60049-8"xsd:string |
| http://purl.uniprot.org/citations/32080306 | http://purl.uniprot.org/core/author | "Lee H."xsd:string |
| http://purl.uniprot.org/citations/32080306 | http://purl.uniprot.org/core/author | "Choi J.H."xsd:string |
| http://purl.uniprot.org/citations/32080306 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32080306 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/32080306 | http://purl.uniprot.org/core/pages | "3050"xsd:string |
| http://purl.uniprot.org/citations/32080306 | http://purl.uniprot.org/core/title | "Histone demethylase KDM4D cooperates with NFIB and MLL1 complex to regulate adipogenic differentiation of C3H10T1/2 mesenchymal stem cells."xsd:string |
| http://purl.uniprot.org/citations/32080306 | http://purl.uniprot.org/core/volume | "10"xsd:string |
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