| http://purl.uniprot.org/citations/32081131 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32081131 | http://www.w3.org/2000/01/rdf-schema#comment | "Polypyrimidine tract-binding protein 1 (PTBP1) is a RNA-binding protein (RBP) expressed throughout B cell development. Deletion of Ptbp1 in mouse pro-B cells results in upregulation of PTBP2 and normal B cell development. We show that PTBP2 compensates for PTBP1 in B cell ontogeny as deletion of both Ptbp1 and Ptbp2 results in a complete block at the pro-B cell stage and a lack of mature B cells. In pro-B cells PTBP1 ensures precise synchronisation of the activity of cyclin dependent kinases at distinct stages of the cell cycle, suppresses S-phase entry and promotes progression into mitosis. PTBP1 controls mRNA abundance and alternative splicing of important cell cycle regulators including CYCLIN-D2, c-MYC, p107 and CDC25B. Our results reveal a previously unrecognised mechanism mediated by a RBP that is essential for B cell ontogeny and integrates transcriptional and post-translational determinants of progression through the cell cycle."xsd:string |
| http://purl.uniprot.org/citations/32081131 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.53557"xsd:string |
| http://purl.uniprot.org/citations/32081131 | http://purl.uniprot.org/core/author | "Turner M."xsd:string |
| http://purl.uniprot.org/citations/32081131 | http://purl.uniprot.org/core/author | "Zarnack K."xsd:string |
| http://purl.uniprot.org/citations/32081131 | http://purl.uniprot.org/core/author | "Smith C.W."xsd:string |
| http://purl.uniprot.org/citations/32081131 | http://purl.uniprot.org/core/author | "Monzon-Casanova E."xsd:string |
| http://purl.uniprot.org/citations/32081131 | http://purl.uniprot.org/core/author | "Tabbada K."xsd:string |
| http://purl.uniprot.org/citations/32081131 | http://purl.uniprot.org/core/author | "Matheson L.S."xsd:string |
| http://purl.uniprot.org/citations/32081131 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32081131 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/32081131 | http://purl.uniprot.org/core/pages | "e53557"xsd:string |
| http://purl.uniprot.org/citations/32081131 | http://purl.uniprot.org/core/title | "Polypyrimidine tract-binding proteins are essential for B cell development."xsd:string |
| http://purl.uniprot.org/citations/32081131 | http://purl.uniprot.org/core/volume | "9"xsd:string |
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