| http://purl.uniprot.org/citations/32081878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32081878 | http://www.w3.org/2000/01/rdf-schema#comment | "Cytoplasmic aggregation of TDP-43 characterizes degenerating neurons in most cases of amyotrophic lateral sclerosis (ALS). Here, we develop an optogenetic TDP-43 variant (opTDP-43), whose multimerization status can be modulated in vivo through external light illumination. Using the translucent zebrafish neuromuscular system, we demonstrate that short-term light stimulation reversibly induces cytoplasmic opTDP-43 mislocalization, but not aggregation, in the spinal motor neuron, leading to an axon outgrowth defect associated with myofiber denervation. In contrast, opTDP-43 forms pathological aggregates in the cytoplasm after longer-term illumination and seeds non-optogenetic TDP-43 aggregation. Furthermore, we find that an ALS-linked mutation in the intrinsically disordered region (IDR) exacerbates the light-dependent opTDP-43 toxicity on locomotor behavior. Together, our results propose that IDR-mediated TDP-43 oligomerization triggers both acute and long-term pathologies of motor neurons, which may be relevant to the pathogenesis and progression of ALS."xsd:string |
| http://purl.uniprot.org/citations/32081878 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-020-14815-x"xsd:string |
| http://purl.uniprot.org/citations/32081878 | http://purl.uniprot.org/core/author | "Handa H."xsd:string |
| http://purl.uniprot.org/citations/32081878 | http://purl.uniprot.org/core/author | "Kawakami K."xsd:string |
| http://purl.uniprot.org/citations/32081878 | http://purl.uniprot.org/core/author | "Asakawa K."xsd:string |
| http://purl.uniprot.org/citations/32081878 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32081878 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/32081878 | http://purl.uniprot.org/core/pages | "1004"xsd:string |
| http://purl.uniprot.org/citations/32081878 | http://purl.uniprot.org/core/title | "Optogenetic modulation of TDP-43 oligomerization accelerates ALS-related pathologies in the spinal motor neurons."xsd:string |
| http://purl.uniprot.org/citations/32081878 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/32081878 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32081878 |
| http://purl.uniprot.org/citations/32081878 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32081878 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MSV7-mappedCitation-32081878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32081878 |
| http://purl.uniprot.org/uniprot/#_A0A0A0N0L3-mappedCitation-32081878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32081878 |
| http://purl.uniprot.org/uniprot/#_A0A0A0N0L6-mappedCitation-32081878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32081878 |
| http://purl.uniprot.org/uniprot/#_A0A0A0N0M3-mappedCitation-32081878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32081878 |
| http://purl.uniprot.org/uniprot/#_A0A0A0N0N3-mappedCitation-32081878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32081878 |
| http://purl.uniprot.org/uniprot/#_B4DRW3-mappedCitation-32081878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32081878 |
| http://purl.uniprot.org/uniprot/#_G3V162-mappedCitation-32081878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32081878 |
| http://purl.uniprot.org/uniprot/#_Q13148-mappedCitation-32081878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32081878 |
| http://purl.uniprot.org/uniprot/#_Q921F2-mappedCitation-32081878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32081878 |
| http://purl.uniprot.org/uniprot/#_Q9H256-mappedCitation-32081878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32081878 |
| http://purl.uniprot.org/uniprot/Q9H256 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32081878 |
| http://purl.uniprot.org/uniprot/A0A0A0N0L3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32081878 |