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http://purl.uniprot.org/citations/32083677http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/32083677http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/32083677http://www.w3.org/2000/01/rdf-schema#comment"

Background

Respiratory syncytial virus (RSV) typically causes winter outbreaks in temperate climates. During summer 2017, the Minnesota Department of Health received a report of increased cases of severe RSV-B infection.

Methods

We compared characteristics of summer 2017 cases with those of 2014-2018 summers. To understand the genetic relatedness among viruses, we performed high-throughput sequencing of RSV from patients with a spectrum of illness from sites in Minnesota and Wisconsin.

Results

From May to September 2017, 58 RSV cases (43 RSV-B) were reported compared to 20-29 cases (3-7 RSV-B) during these months in other years. Median age and frequency of comorbidities were similar, but 55% (24/43) were admitted to the ICU in 2017 compared to 12% in preceding 3 years (odds ratio, 4.84, Pā€…<ā€….01). Sequencing was performed on 137 specimens from March 2016 to March 2018. Outbreak cases formed a unique clade sharing a single conserved nonsynonymous change in the SH gene. We observed increased cases during the following winter season, when the new lineage was the predominant strain.

Conclusions

We identified an outbreak of severe RSV-B disease associated with a new genetic lineage among urban Minnesota children during a time of expected low RSV circulation."xsd:string
http://purl.uniprot.org/citations/32083677http://purl.org/dc/terms/identifier"doi:10.1093/infdis/jiaa075"xsd:string
http://purl.uniprot.org/citations/32083677http://purl.uniprot.org/core/author"Christensen J."xsd:string
http://purl.uniprot.org/citations/32083677http://purl.uniprot.org/core/author"Christensen J."xsd:string
http://purl.uniprot.org/citations/32083677http://purl.uniprot.org/core/author"Martin K."xsd:string
http://purl.uniprot.org/citations/32083677http://purl.uniprot.org/core/author"Martin K."xsd:string
http://purl.uniprot.org/citations/32083677http://purl.uniprot.org/core/author"Wang X."xsd:string
http://purl.uniprot.org/citations/32083677http://purl.uniprot.org/core/author"Wang X."xsd:string
http://purl.uniprot.org/citations/32083677http://purl.uniprot.org/core/author"Thielen B.K."xsd:string
http://purl.uniprot.org/citations/32083677http://purl.uniprot.org/core/author"Thielen B.K."xsd:string
http://purl.uniprot.org/citations/32083677http://purl.uniprot.org/core/author"Strain A.K."xsd:string
http://purl.uniprot.org/citations/32083677http://purl.uniprot.org/core/author"Strain A.K."xsd:string
http://purl.uniprot.org/citations/32083677http://purl.uniprot.org/core/author"Lynfield R."xsd:string
http://purl.uniprot.org/citations/32083677http://purl.uniprot.org/core/author"Lynfield R."xsd:string
http://purl.uniprot.org/citations/32083677http://purl.uniprot.org/core/author"Ferrieri P."xsd:string
http://purl.uniprot.org/citations/32083677http://purl.uniprot.org/core/author"Ferrieri P."xsd:string
http://purl.uniprot.org/citations/32083677http://purl.uniprot.org/core/author"Shilts M.H."xsd:string
http://purl.uniprot.org/citations/32083677http://purl.uniprot.org/core/author"Shilts M.H."xsd:string
http://purl.uniprot.org/citations/32083677http://purl.uniprot.org/core/author"Bistodeau S."xsd:string
http://purl.uniprot.org/citations/32083677http://purl.uniprot.org/core/author"Bistodeau S."xsd:string
http://purl.uniprot.org/citations/32083677http://purl.uniprot.org/core/author"Bye E."xsd:string
http://purl.uniprot.org/citations/32083677http://purl.uniprot.org/core/author"Bye E."xsd:string
http://purl.uniprot.org/citations/32083677http://purl.uniprot.org/core/author"Como-Sabetti K."xsd:string
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