| http://purl.uniprot.org/citations/32094297 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32094297 | http://www.w3.org/2000/01/rdf-schema#comment | "T-cell immunoglobulin and mucin domain-containing molecule 3 (TIM-3), a potential immunotherapeutic target for cancer, has been shown to display diverse characteristics in a context-dependent manner. Thus, it would be useful to delineate the precise functional features of TIM-3 in a given situation. Here, we report that glial TIM-3 shows distinctive properties in the brain tumor microenvironment. TIM-3 was expressed on both growing tumor cells and their surrounding cells including glia and T cells in an orthotopic mouse glioma model. The expression pattern of TIM-3 was distinct from those of other immune checkpoint molecules in tumor-exposed and tumor-infiltrating glia. Comparison of cells from tumor-bearing and contralateral hemispheres of a glioma model showed that TIM-3 expression was lower in tumor-infiltrating CD11b+CD45mid glial cells but higher in tumor-infiltrating CD8+ T cells. In TIM-3 mutant mice with intracellular signaling defects and Cre-inducible TIM-3 mice, TIM-3 affected the expression of several immune-associated molecules including iNOS and PD-L1 in primary glia-exposed conditioned media (CM) from brain tumors. Further, TIM-3 was cross-regulated by TLR2, but not by TLR4, in brain tumor CM- or Pam3CSK4-exposed glia. In addition, following exposure to tumor CM, IFNγ production was lower in T cells cocultured with TIM-3-defective glia than with normal glia. Collectively, these findings suggest that glial TIM-3 actively and distinctively responds to brain tumor, and plays specific intracellular and intercellular immunoregulatory roles that might be different from TIM-3 on T cells in the brain tumor microenvironment. SIGNIFICANCE: TIM-3 is typically thought of as a T-cell checkpoint receptor. This study demonstrates a role for TIM-3 in mediating myeloid cell responses in glioblastoma."xsd:string |
| http://purl.uniprot.org/citations/32094297 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-19-2834"xsd:string |
| http://purl.uniprot.org/citations/32094297 | http://purl.uniprot.org/core/author | "Kim H.S."xsd:string |
| http://purl.uniprot.org/citations/32094297 | http://purl.uniprot.org/core/author | "Lee S.J."xsd:string |
| http://purl.uniprot.org/citations/32094297 | http://purl.uniprot.org/core/author | "Kim K.S."xsd:string |
| http://purl.uniprot.org/citations/32094297 | http://purl.uniprot.org/core/author | "Yoon H.J."xsd:string |
| http://purl.uniprot.org/citations/32094297 | http://purl.uniprot.org/core/author | "Kim S.S."xsd:string |
| http://purl.uniprot.org/citations/32094297 | http://purl.uniprot.org/core/author | "Park E.J."xsd:string |
| http://purl.uniprot.org/citations/32094297 | http://purl.uniprot.org/core/author | "Chang C.Y."xsd:string |
| http://purl.uniprot.org/citations/32094297 | http://purl.uniprot.org/core/author | "Kane L.P."xsd:string |
| http://purl.uniprot.org/citations/32094297 | http://purl.uniprot.org/core/author | "Koh H.S."xsd:string |
| http://purl.uniprot.org/citations/32094297 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32094297 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/32094297 | http://purl.uniprot.org/core/pages | "1833-1845"xsd:string |
| http://purl.uniprot.org/citations/32094297 | http://purl.uniprot.org/core/title | "Glial TIM-3 Modulates Immune Responses in the Brain Tumor Microenvironment."xsd:string |
| http://purl.uniprot.org/citations/32094297 | http://purl.uniprot.org/core/volume | "80"xsd:string |
| http://purl.uniprot.org/citations/32094297 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32094297 |
| http://purl.uniprot.org/citations/32094297 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32094297 |
| http://purl.uniprot.org/uniprot/#_A0A077S2U6-mappedCitation-32094297 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32094297 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J1E9-mappedCitation-32094297 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32094297 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J1F0-mappedCitation-32094297 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32094297 |
| http://purl.uniprot.org/uniprot/#_A2BHU8-mappedCitation-32094297 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32094297 |
| http://purl.uniprot.org/uniprot/#_D3Z3I4-mappedCitation-32094297 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32094297 |
| http://purl.uniprot.org/uniprot/#_G3X8Y8-mappedCitation-32094297 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32094297 |