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| http://purl.uniprot.org/citations/32097653 | http://www.w3.org/2000/01/rdf-schema#comment | "Most adult neurons and glia originate from radial glial progenitors (RGs), a type of stem cell typically extending from the apical to the basal side of the developing cortex. Precise regulation of the choice between RG self-renewal and differentiation is critical for normal development, but the mechanisms underlying this transition remain elusive. We show that the non-canonical tubulin Tuba8, transiently expressed in cortical progenitors, drives differentiation of RGs into apical intermediate progenitors, a more restricted progenitor type lacking attachment to the basal lamina. This effect depends on the unique C-terminal sequence of Tuba8 that antagonizes tubulin tyrosination and Δ2 cleavage, two post-translational modifications (PTMs) essential for RG fiber maintenance and the switch between direct and indirect neurogenesis and ultimately distinct neuronal lineage outcomes. Our work uncovers an instructive role of a developmentally regulated tubulin isotype in progenitor differentiation and provides new insights into biological functions of the cellular tubulin PTM "code.""xsd:string |
| http://purl.uniprot.org/citations/32097653 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2020.01.036"xsd:string |
| http://purl.uniprot.org/citations/32097653 | http://purl.uniprot.org/core/author | "Kodama T."xsd:string |
| http://purl.uniprot.org/citations/32097653 | http://purl.uniprot.org/core/author | "Sahara S."xsd:string |
| http://purl.uniprot.org/citations/32097653 | http://purl.uniprot.org/core/author | "Kawakami Y."xsd:string |
| http://purl.uniprot.org/citations/32097653 | http://purl.uniprot.org/core/author | "Makeyev E.V."xsd:string |
| http://purl.uniprot.org/citations/32097653 | http://purl.uniprot.org/core/author | "Ramos S.I."xsd:string |
| http://purl.uniprot.org/citations/32097653 | http://purl.uniprot.org/core/author | "Salierno M."xsd:string |
| http://purl.uniprot.org/citations/32097653 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32097653 | http://purl.uniprot.org/core/name | "Dev Cell"xsd:string |
| http://purl.uniprot.org/citations/32097653 | http://purl.uniprot.org/core/pages | "477-491.e8"xsd:string |
| http://purl.uniprot.org/citations/32097653 | http://purl.uniprot.org/core/title | "Tuba8 Drives Differentiation of Cortical Radial Glia into Apical Intermediate Progenitors by Tuning Modifications of Tubulin C Termini."xsd:string |
| http://purl.uniprot.org/citations/32097653 | http://purl.uniprot.org/core/volume | "52"xsd:string |
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