| http://purl.uniprot.org/citations/32101751 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32101751 | http://www.w3.org/2000/01/rdf-schema#comment | "TRAF-interacting protein with a forkhead-associated domain B (TIFAB) is implicated in myeloid malignancies with deletion of chromosome 5q. Employing a combination of proteomic and genetic approaches, we find that TIFAB regulates ubiquitin-specific peptidase 15 (USP15) ubiquitin hydrolase activity. Expression of TIFAB in hematopoietic stem/progenitor cells (HSPCs) permits USP15 signaling to substrates, including MDM2 and KEAP1, and mitigates p53 expression. Consequently, TIFAB-deficient HSPCs exhibit compromised USP15 signaling and are sensitized to hematopoietic stress by derepression of p53. In MLL-AF9 leukemia, deletion of TIFAB increases p53 signaling and correspondingly decreases leukemic cell function and development of leukemia. Restoring USP15 expression partially rescues the function of TIFAB-deficient MLL-AF9 cells. Conversely, elevated TIFAB represses p53, increases leukemic progenitor function, and correlates with MLL gene expression programs in leukemia patients. Our studies uncover a function of TIFAB as an effector of USP15 activity and rheostat of p53 signaling in stressed and malignant HSPCs."xsd:string |
| http://purl.uniprot.org/citations/32101751 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2020.01.093"xsd:string |
| http://purl.uniprot.org/citations/32101751 | http://purl.uniprot.org/core/author | "Choi K."xsd:string |
| http://purl.uniprot.org/citations/32101751 | http://purl.uniprot.org/core/author | "Greis K.D."xsd:string |
| http://purl.uniprot.org/citations/32101751 | http://purl.uniprot.org/core/author | "Inoue J.I."xsd:string |
| http://purl.uniprot.org/citations/32101751 | http://purl.uniprot.org/core/author | "Romano L."xsd:string |
| http://purl.uniprot.org/citations/32101751 | http://purl.uniprot.org/core/author | "Starczynowski D.T."xsd:string |
| http://purl.uniprot.org/citations/32101751 | http://purl.uniprot.org/core/author | "Varney M.E."xsd:string |
| http://purl.uniprot.org/citations/32101751 | http://purl.uniprot.org/core/author | "Niederkorn M."xsd:string |
| http://purl.uniprot.org/citations/32101751 | http://purl.uniprot.org/core/author | "Pujato M.A."xsd:string |
| http://purl.uniprot.org/citations/32101751 | http://purl.uniprot.org/core/author | "Hueneman K."xsd:string |
| http://purl.uniprot.org/citations/32101751 | http://purl.uniprot.org/core/author | "Meetei R."xsd:string |
| http://purl.uniprot.org/citations/32101751 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32101751 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/32101751 | http://purl.uniprot.org/core/pages | "2776-2790.e6"xsd:string |
| http://purl.uniprot.org/citations/32101751 | http://purl.uniprot.org/core/title | "TIFAB Regulates USP15-Mediated p53 Signaling during Stressed and Malignant Hematopoiesis."xsd:string |
| http://purl.uniprot.org/citations/32101751 | http://purl.uniprot.org/core/volume | "30"xsd:string |
| http://purl.uniprot.org/citations/32101751 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32101751 |
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| http://purl.uniprot.org/uniprot/Q8JZM6#attribution-02FE5E3FF81B346E88E65379A497CD2C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/32101751 |
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| http://purl.uniprot.org/uniprot/#_A0A087WXZ1-mappedCitation-32101751 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32101751 |