| http://purl.uniprot.org/citations/32107331 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32107331 | http://www.w3.org/2000/01/rdf-schema#comment | "The human fetal γ-globin gene is repressed in the adult stage through complex regulatory mechanisms involving transcription factors and epigenetic modifiers. Reversing γ-globin repression, or maintaining its expression by manipulating regulatory mechanisms, has become a major clinical goal in the treatment of β-hemoglobinopathies. Here, we identify the orphan nuclear receptor Coup-TFII (NR2F2/ARP-1) as an embryonic/fetal stage activator of γ-globin expression. We show that Coup-TFII is expressed in early erythropoiesis of yolk sac origin, together with embryonic/fetal globins. When overexpressed in adult cells (including peripheral blood cells from human healthy donors and β039 thalassemic patients) Coup-TFII activates the embryonic/fetal globins genes, overcoming the repression imposed by the adult erythroid environment. Conversely, the knock-out of Coup-TFII increases the β/γ+β globin ratio. Molecular analysis indicates that Coup-TFII binds in vivo to the β-locus and contributes to its conformation. Overall, our data identify Coup-TFII as a specific activator of the γ-globin gene."xsd:string |
| http://purl.uniprot.org/citations/32107331 | http://purl.org/dc/terms/identifier | "doi:10.3324/haematol.2019.241224"xsd:string |
| http://purl.uniprot.org/citations/32107331 | http://purl.uniprot.org/core/author | "Nakamura Y."xsd:string |
| http://purl.uniprot.org/citations/32107331 | http://purl.uniprot.org/core/author | "Barabino S.M.L."xsd:string |
| http://purl.uniprot.org/citations/32107331 | http://purl.uniprot.org/core/author | "Moi P."xsd:string |
| http://purl.uniprot.org/citations/32107331 | http://purl.uniprot.org/core/author | "Ottolenghi S."xsd:string |
| http://purl.uniprot.org/citations/32107331 | http://purl.uniprot.org/core/author | "Strouboulis J."xsd:string |
| http://purl.uniprot.org/citations/32107331 | http://purl.uniprot.org/core/author | "Elangovan S."xsd:string |
| http://purl.uniprot.org/citations/32107331 | http://purl.uniprot.org/core/author | "Marini M.G."xsd:string |
| http://purl.uniprot.org/citations/32107331 | http://purl.uniprot.org/core/author | "Gasparri F."xsd:string |
| http://purl.uniprot.org/citations/32107331 | http://purl.uniprot.org/core/author | "Marongiu M.F."xsd:string |
| http://purl.uniprot.org/citations/32107331 | http://purl.uniprot.org/core/author | "Cantu C."xsd:string |
| http://purl.uniprot.org/citations/32107331 | http://purl.uniprot.org/core/author | "Fugazza C."xsd:string |
| http://purl.uniprot.org/citations/32107331 | http://purl.uniprot.org/core/author | "Ronchi A.E."xsd:string |
| http://purl.uniprot.org/citations/32107331 | http://purl.uniprot.org/core/author | "Manunza L."xsd:string |
| http://purl.uniprot.org/citations/32107331 | http://purl.uniprot.org/core/author | "Barbarani G."xsd:string |
| http://purl.uniprot.org/citations/32107331 | http://purl.uniprot.org/core/author | "Font-Monclus I."xsd:string |
| http://purl.uniprot.org/citations/32107331 | http://purl.uniprot.org/core/author | "Giolitto S."xsd:string |
| http://purl.uniprot.org/citations/32107331 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/32107331 | http://purl.uniprot.org/core/name | "Haematologica"xsd:string |
| http://purl.uniprot.org/citations/32107331 | http://purl.uniprot.org/core/pages | "474-482"xsd:string |
| http://purl.uniprot.org/citations/32107331 | http://purl.uniprot.org/core/title | "The Coup-TFII orphan nuclear receptor is an activator of the gamma-globin gene."xsd:string |
| http://purl.uniprot.org/citations/32107331 | http://purl.uniprot.org/core/volume | "106"xsd:string |
| http://purl.uniprot.org/citations/32107331 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32107331 |