| http://purl.uniprot.org/citations/32113654 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32113654 | http://www.w3.org/2000/01/rdf-schema#comment | "Non-small cell lung cancer (NSCLC) is associated with high mortality rates worldwide. The costimulatory molecule, B7-H4, a member of the B7 family, plays an important role in immune regulation, mainly by inhibiting the proliferation of T cells to achieve a negative regulatory T cell immune response. The mechanism of action of B7-H4 in non-small cell lung cancer is unknown at present. Tumor tissues from 71 patients subjected to radical pneumonectomy were examined, along with NSCLC cells and BALB/c mice. Among the 71 NSCLC cases, overall and recurrence-free survival rates were significantly lower in those displaying high B7-H4 expression. Mechanistic analyses showed that B7-H4 promoted the growth and metastasis of non-small cell lung cancer tumor tissues in mice through effects on CD8+ T cell apoptosis. Data from western blot experiments further suggested that B7-H4 induced CD8+ T cell death, both in vitro and in vivo, and affecting the PD-1/Stat3 pathway and promoting immune escape of tumor cells. Our collective findings support the potential utility of B7-H4 gene expression as a marker of NSCLC prognosis and provide a novel strategy for targeted therapy."xsd:string |
| http://purl.uniprot.org/citations/32113654 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.humimm.2020.02.004"xsd:string |
| http://purl.uniprot.org/citations/32113654 | http://purl.uniprot.org/core/author | "Fan D."xsd:string |
| http://purl.uniprot.org/citations/32113654 | http://purl.uniprot.org/core/author | "Yuan L."xsd:string |
| http://purl.uniprot.org/citations/32113654 | http://purl.uniprot.org/core/author | "Ye J."xsd:string |
| http://purl.uniprot.org/citations/32113654 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32113654 | http://purl.uniprot.org/core/name | "Hum Immunol"xsd:string |
| http://purl.uniprot.org/citations/32113654 | http://purl.uniprot.org/core/pages | "254-261"xsd:string |
| http://purl.uniprot.org/citations/32113654 | http://purl.uniprot.org/core/title | "The B7-H4 gene induces immune escape partly via upregulating the PD-1/Stat3 pathway in non-small cell lung cancer."xsd:string |
| http://purl.uniprot.org/citations/32113654 | http://purl.uniprot.org/core/volume | "81"xsd:string |
| http://purl.uniprot.org/citations/32113654 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32113654 |
| http://purl.uniprot.org/citations/32113654 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32113654 |
| http://purl.uniprot.org/uniprot/#_Q7Z7D3-mappedCitation-32113654 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32113654 |
| http://purl.uniprot.org/uniprot/#_Q7TSP5-mappedCitation-32113654 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32113654 |
| http://purl.uniprot.org/uniprot/Q7TSP5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32113654 |
| http://purl.uniprot.org/uniprot/Q7Z7D3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32113654 |