| http://purl.uniprot.org/citations/32118582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32118582 | http://www.w3.org/2000/01/rdf-schema#comment | "The eicosanoid lipoxin A4 (LXA4) has emerging roles in lymphocyte-driven diseases. We identified reduced LXA4 levels in posterior segment uveitis patients and investigated the role of LXA4 in the pathogenesis of experimental autoimmune uveitis (EAU). Immunization for EAU with a retinal self-antigen caused selective downregulation of LXA4 in lymph nodes draining the site of immunization, while at the same time amplifying LXA4 in the inflamed target tissue. T cell effector function, migration and glycolytic responses were amplified in LXA4-deficient mice, which correlated with more severe pathology, whereas LXA4 treatment attenuated disease. In vivo deletion or supplementation of LXA4 identified modulation of CC-chemokine receptor 7 (CCR7) and sphingosine 1-phosphate receptor-1 (S1PR1) expression and glucose metabolism in CD4+ T cells as potential mechanisms for LXA4 regulation of T cell effector function and trafficking. Our results demonstrate the intrinsic lymph node LXA4 pathway as a significant checkpoint in the development and severity of adaptive immunity."xsd:string |
| http://purl.uniprot.org/citations/32118582 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.51102"xsd:string |
| http://purl.uniprot.org/citations/32118582 | http://purl.uniprot.org/core/author | "Wei J."xsd:string |
| http://purl.uniprot.org/citations/32118582 | http://purl.uniprot.org/core/author | "Gronert K."xsd:string |
| http://purl.uniprot.org/citations/32118582 | http://purl.uniprot.org/core/author | "Caspi R.R."xsd:string |
| http://purl.uniprot.org/citations/32118582 | http://purl.uniprot.org/core/author | "Horai R."xsd:string |
| http://purl.uniprot.org/citations/32118582 | http://purl.uniprot.org/core/author | "Mattapallil M.J."xsd:string |
| http://purl.uniprot.org/citations/32118582 | http://purl.uniprot.org/core/author | "Modi A.P."xsd:string |
| http://purl.uniprot.org/citations/32118582 | http://purl.uniprot.org/core/author | "Sen H.N."xsd:string |
| http://purl.uniprot.org/citations/32118582 | http://purl.uniprot.org/core/author | "Jittayasothorn Y."xsd:string |
| http://purl.uniprot.org/citations/32118582 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32118582 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/32118582 | http://purl.uniprot.org/core/pages | "e51102"xsd:string |
| http://purl.uniprot.org/citations/32118582 | http://purl.uniprot.org/core/title | "A novel role for lipoxin A4 in driving a lymph node-eye axis that controls autoimmunity to the neuroretina."xsd:string |
| http://purl.uniprot.org/citations/32118582 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/32118582 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32118582 |
| http://purl.uniprot.org/citations/32118582 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32118582 |
| http://purl.uniprot.org/uniprot/#_E9QA93-mappedCitation-32118582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32118582 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SW45-mappedCitation-32118582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32118582 |
| http://purl.uniprot.org/uniprot/#_E9Q6H6-mappedCitation-32118582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32118582 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BPU6-mappedCitation-32118582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32118582 |
| http://purl.uniprot.org/uniprot/#_O88536-mappedCitation-32118582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32118582 |
| http://purl.uniprot.org/uniprot/#_P48999-mappedCitation-32118582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32118582 |
| http://purl.uniprot.org/uniprot/#_Q3TC68-mappedCitation-32118582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32118582 |