| http://purl.uniprot.org/citations/32123388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32123388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32123388 | http://www.w3.org/2000/01/rdf-schema#comment | "Carboxysomes are bacterial microcompartments that function as the centerpiece of the bacterial CO2-concentrating mechanism by facilitating high CO2 concentrations near the carboxylase Rubisco. The carboxysome self-assembles from thousands of individual proteins into icosahedral-like particles with a dense enzyme cargo encapsulated within a proteinaceous shell. In the case of the α-carboxysome, there is little molecular insight into protein-protein interactions that drive the assembly process. Here, studies on the α-carboxysome from Halothiobacillus neapolitanus demonstrate that Rubisco interacts with the N terminus of CsoS2, a multivalent, intrinsically disordered protein. X-ray structural analysis of the CsoS2 interaction motif bound to Rubisco reveals a series of conserved electrostatic interactions that are only made with properly assembled hexadecameric Rubisco. Although biophysical measurements indicate that this single interaction is weak, its implicit multivalency induces high-affinity binding through avidity. Taken together, our results indicate that CsoS2 acts as an interaction hub to condense Rubisco and enable efficient α-carboxysome formation."xsd:string |
| http://purl.uniprot.org/citations/32123388 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41594-020-0387-7"xsd:string |
| http://purl.uniprot.org/citations/32123388 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41594-020-0387-7"xsd:string |
| http://purl.uniprot.org/citations/32123388 | http://purl.uniprot.org/core/author | "Oltrogge L.M."xsd:string |
| http://purl.uniprot.org/citations/32123388 | http://purl.uniprot.org/core/author | "Oltrogge L.M."xsd:string |
| http://purl.uniprot.org/citations/32123388 | http://purl.uniprot.org/core/author | "Savage D.F."xsd:string |
| http://purl.uniprot.org/citations/32123388 | http://purl.uniprot.org/core/author | "Savage D.F."xsd:string |
| http://purl.uniprot.org/citations/32123388 | http://purl.uniprot.org/core/author | "Chaijarasphong T."xsd:string |
| http://purl.uniprot.org/citations/32123388 | http://purl.uniprot.org/core/author | "Chaijarasphong T."xsd:string |
| http://purl.uniprot.org/citations/32123388 | http://purl.uniprot.org/core/author | "Chen A.W."xsd:string |
| http://purl.uniprot.org/citations/32123388 | http://purl.uniprot.org/core/author | "Chen A.W."xsd:string |
| http://purl.uniprot.org/citations/32123388 | http://purl.uniprot.org/core/author | "Bolin E.R."xsd:string |
| http://purl.uniprot.org/citations/32123388 | http://purl.uniprot.org/core/author | "Bolin E.R."xsd:string |
| http://purl.uniprot.org/citations/32123388 | http://purl.uniprot.org/core/author | "Marqusee S."xsd:string |
| http://purl.uniprot.org/citations/32123388 | http://purl.uniprot.org/core/author | "Marqusee S."xsd:string |
| http://purl.uniprot.org/citations/32123388 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32123388 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32123388 | http://purl.uniprot.org/core/name | "Nat. Struct. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/32123388 | http://purl.uniprot.org/core/name | "Nat. Struct. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/32123388 | http://purl.uniprot.org/core/pages | "281-287"xsd:string |
| http://purl.uniprot.org/citations/32123388 | http://purl.uniprot.org/core/pages | "281-287"xsd:string |
| http://purl.uniprot.org/citations/32123388 | http://purl.uniprot.org/core/title | "Multivalent interactions between CsoS2 and Rubisco mediate alpha-carboxysome formation."xsd:string |
| http://purl.uniprot.org/citations/32123388 | http://purl.uniprot.org/core/title | "Multivalent interactions between CsoS2 and Rubisco mediate alpha-carboxysome formation."xsd:string |