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| http://purl.uniprot.org/citations/32127556 | http://www.w3.org/2000/01/rdf-schema#comment | "Co-expression of Yin Yang 1 (YY1) is required for the full function of the transcription factor, PLZF, which is essential for the development of natural killer T cell (NKT cell) effector functions. Discordant expression of YY1 and PLZF, therefore, might define NKT cell subsets with distinct effector functions. A subset of NKT cells was identified that expressed low levels of YY1. YY1lo NKT cells were found in all tissues, had a mature phenotype and, distinct from other NKT cells, expressed almost no ThPOK or Tbet. When activated, YY1lo NKT cells produced little IL-4 or IFN-γ. YY1lo NKT cells were found to constitutively transcribe IL-10 mRNA and, accordingly, produced IL-10 upon primary activation. Finally, we find that tumor infiltrating NKT cells are highly enriched for the YY1lo subset. Low YY1 expression, therefore, defines a previously unrecognized NKT cell subset that is committed to producing IL-10."xsd:string |
| http://purl.uniprot.org/citations/32127556 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-020-60229-6"xsd:string |
| http://purl.uniprot.org/citations/32127556 | http://purl.uniprot.org/core/author | "Denzin L.K."xsd:string |
| http://purl.uniprot.org/citations/32127556 | http://purl.uniprot.org/core/author | "Sant'Angelo D.B."xsd:string |
| http://purl.uniprot.org/citations/32127556 | http://purl.uniprot.org/core/author | "Darcy P.W."xsd:string |
| http://purl.uniprot.org/citations/32127556 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32127556 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/32127556 | http://purl.uniprot.org/core/pages | "3897"xsd:string |
| http://purl.uniprot.org/citations/32127556 | http://purl.uniprot.org/core/title | "YY1lo NKT cells are dedicated IL-10 producers."xsd:string |
| http://purl.uniprot.org/citations/32127556 | http://purl.uniprot.org/core/volume | "10"xsd:string |
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