| http://purl.uniprot.org/citations/32128853 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32128853 | http://www.w3.org/2000/01/rdf-schema#comment | "Protein prenylation is essential for many cellular processes including signal transduction, cytoskeletal reorganization, and membrane trafficking. Here, we identify a novel type of protein prenyltransferase, which we named geranylgeranyltransferase type-III (GGTase-III). GGTase-III consists of prenyltransferase alpha subunit repeat containing 1 (PTAR1) and the β subunit of RabGGTase. Using a biotinylated geranylgeranyl analogue, we identified the Golgi SNARE protein Ykt6 as a substrate of GGTase-III. GGTase-III transfers a geranylgeranyl group to mono-farnesylated Ykt6, generating doubly prenylated Ykt6. The crystal structure of GGTase-III in complex with Ykt6 provides structural basis for Ykt6 double prenylation. In GGTase-III-deficient cells, Ykt6 remained in a singly prenylated form, and the Golgi SNARE complex assembly was severely impaired. Consequently, the Golgi apparatus was structurally disorganized, and intra-Golgi protein trafficking was delayed. Our findings reveal a fourth type of protein prenyltransferase that generates geranylgeranyl-farnesyl Ykt6. Double prenylation of Ykt6 is essential for the structural and functional organization of the Golgi apparatus."xsd:string |
| http://purl.uniprot.org/citations/32128853 | http://purl.org/dc/terms/identifier | "doi:10.15252/embj.2019104120"xsd:string |
| http://purl.uniprot.org/citations/32128853 | http://purl.uniprot.org/core/author | "Cheng J."xsd:string |
| http://purl.uniprot.org/citations/32128853 | http://purl.uniprot.org/core/author | "Goto K."xsd:string |
| http://purl.uniprot.org/citations/32128853 | http://purl.uniprot.org/core/author | "Horiuchi H."xsd:string |
| http://purl.uniprot.org/citations/32128853 | http://purl.uniprot.org/core/author | "Sato Y."xsd:string |
| http://purl.uniprot.org/citations/32128853 | http://purl.uniprot.org/core/author | "Fukai S."xsd:string |
| http://purl.uniprot.org/citations/32128853 | http://purl.uniprot.org/core/author | "Fujimoto T."xsd:string |
| http://purl.uniprot.org/citations/32128853 | http://purl.uniprot.org/core/author | "Kubo H."xsd:string |
| http://purl.uniprot.org/citations/32128853 | http://purl.uniprot.org/core/author | "Sakata N."xsd:string |
| http://purl.uniprot.org/citations/32128853 | http://purl.uniprot.org/core/author | "Goto-Ito S."xsd:string |
| http://purl.uniprot.org/citations/32128853 | http://purl.uniprot.org/core/author | "Masumoto H."xsd:string |
| http://purl.uniprot.org/citations/32128853 | http://purl.uniprot.org/core/author | "Yamagata A."xsd:string |
| http://purl.uniprot.org/citations/32128853 | http://purl.uniprot.org/core/author | "Shirakawa R."xsd:string |
| http://purl.uniprot.org/citations/32128853 | http://purl.uniprot.org/core/author | "Wakayama S."xsd:string |
| http://purl.uniprot.org/citations/32128853 | http://purl.uniprot.org/core/author | "Trinh D.A."xsd:string |
| http://purl.uniprot.org/citations/32128853 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32128853 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/32128853 | http://purl.uniprot.org/core/pages | "e104120"xsd:string |
| http://purl.uniprot.org/citations/32128853 | http://purl.uniprot.org/core/title | "A SNARE geranylgeranyltransferase essential for the organization of the Golgi apparatus."xsd:string |
| http://purl.uniprot.org/citations/32128853 | http://purl.uniprot.org/core/volume | "39"xsd:string |
| http://purl.uniprot.org/citations/32128853 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32128853 |
| http://purl.uniprot.org/citations/32128853 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32128853 |
| http://purl.uniprot.org/uniprot/#_A4D2J0-mappedCitation-32128853 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32128853 |