| http://purl.uniprot.org/citations/32134507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32134507 | http://www.w3.org/2000/01/rdf-schema#comment | "Serotonin transporter (SERT) is involved in serotonergic system regulation and in the pathophysiology/therapeutics of serotonin-/SERT-related diseases such as obsessive-compulsive disorder, depression, autism, and schizophrenia. We recently revealed that diacylglycerol (DG) kinase (DGK) δ induces ubiquitination/degradation of SERT in a DGK activity-dependent manner through Praja-1 E3 ubiquitin-protein ligase. However, it is still unclear how Praja-1 activity is regulated by DGKδ. Here, we reveal that 1-stearoyl-2-docosahexaenoyl (18:0/22:6)-phosphatidic acid (PA) and 18:0/22:6-DG are simultaneously decreased and accumulated, respectively, in the DGKδ-knockout mouse brain, indicating that DGKδ selectively phosphorylates 18:0/22:6-DG to generate 18:0/22:6-PA. Moreover, we find that 18:0/22:6-PA selectively binds to Praja-1 and enhances its activity. These results strongly suggest that 18:0/22:6-PA generated by DGKδ activates Praja-1 to degrade SERT in the brain."xsd:string |
| http://purl.uniprot.org/citations/32134507 | http://purl.org/dc/terms/identifier | "doi:10.1002/1873-3468.13765"xsd:string |
| http://purl.uniprot.org/citations/32134507 | http://purl.uniprot.org/core/author | "Lu Q."xsd:string |
| http://purl.uniprot.org/citations/32134507 | http://purl.uniprot.org/core/author | "Murakami Y."xsd:string |
| http://purl.uniprot.org/citations/32134507 | http://purl.uniprot.org/core/author | "Sakai H."xsd:string |
| http://purl.uniprot.org/citations/32134507 | http://purl.uniprot.org/core/author | "Asami M."xsd:string |
| http://purl.uniprot.org/citations/32134507 | http://purl.uniprot.org/core/author | "Murakami C."xsd:string |
| http://purl.uniprot.org/citations/32134507 | http://purl.uniprot.org/core/author | "Sakane F."xsd:string |
| http://purl.uniprot.org/citations/32134507 | http://purl.uniprot.org/core/author | "Usuki T."xsd:string |
| http://purl.uniprot.org/citations/32134507 | http://purl.uniprot.org/core/author | "Hoshino F."xsd:string |
| http://purl.uniprot.org/citations/32134507 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32134507 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/32134507 | http://purl.uniprot.org/core/pages | "1787-1796"xsd:string |
| http://purl.uniprot.org/citations/32134507 | http://purl.uniprot.org/core/title | "1-Stearoyl-2-docosahexaenoyl-phosphatidic acid interacts with and activates Praja-1, the E3 ubiquitin ligase acting on the serotonin transporter in the brain."xsd:string |
| http://purl.uniprot.org/citations/32134507 | http://purl.uniprot.org/core/volume | "594"xsd:string |
| http://purl.uniprot.org/citations/32134507 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32134507 |
| http://purl.uniprot.org/citations/32134507 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32134507 |
| http://purl.uniprot.org/uniprot/#_A0JLS7-mappedCitation-32134507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32134507 |
| http://purl.uniprot.org/uniprot/#_B1AXU3-mappedCitation-32134507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32134507 |
| http://purl.uniprot.org/uniprot/#_B1AXU4-mappedCitation-32134507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32134507 |
| http://purl.uniprot.org/uniprot/#_Q32MU4-mappedCitation-32134507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32134507 |
| http://purl.uniprot.org/uniprot/#_Q05CG5-mappedCitation-32134507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32134507 |
| http://purl.uniprot.org/uniprot/#_O55176-mappedCitation-32134507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32134507 |
| http://purl.uniprot.org/uniprot/#_Q3UXQ1-mappedCitation-32134507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32134507 |