| http://purl.uniprot.org/citations/32139701 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32139701 | http://www.w3.org/2000/01/rdf-schema#comment | "Tumor metastasis is a hallmark of cancer. Metastatic cancer cells often reside in distal tissues and organs in their dormant state. Mechanisms underlying the pre-metastatic niche formation are poorly understood. Here we show that in a colorectal cancer (CRC) model, primary tumors release integrin beta-like 1 (ITGBL1)-rich extracellular vesicles (EVs) to the circulation to activate resident fibroblasts in remote organs. The activated fibroblasts induce the pre-metastatic niche formation and promote metastatic cancer growth by secreting pro-inflammatory cytokine, such as IL-6 and IL-8. Mechanistically, the primary CRC-derived ITGBL1-enriched EVs stimulate the TNFAIP3-mediated NF-κB signaling pathway to activate fibroblasts. Consequently, the activated fibroblasts produce high levels of pro-inflammatory cytokines to promote metastatic cancer growth. These findings uncover a tumor-stromal interaction in the metastatic tumor microenvironment and an intimate signaling communication between primary tumors and metastases through the ITGBL1-loaded EVs. Targeting the EVs-ITGBL1-CAFs-TNFAIP3-NF-κB signaling axis provides an attractive approach for treating metastatic diseases."xsd:string |
| http://purl.uniprot.org/citations/32139701 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-020-14869-x"xsd:string |
| http://purl.uniprot.org/citations/32139701 | http://purl.uniprot.org/core/author | "Cao Y."xsd:string |
| http://purl.uniprot.org/citations/32139701 | http://purl.uniprot.org/core/author | "Feng Y."xsd:string |
| http://purl.uniprot.org/citations/32139701 | http://purl.uniprot.org/core/author | "Jia R."xsd:string |
| http://purl.uniprot.org/citations/32139701 | http://purl.uniprot.org/core/author | "Li R."xsd:string |
| http://purl.uniprot.org/citations/32139701 | http://purl.uniprot.org/core/author | "Li Q."xsd:string |
| http://purl.uniprot.org/citations/32139701 | http://purl.uniprot.org/core/author | "Liu N."xsd:string |
| http://purl.uniprot.org/citations/32139701 | http://purl.uniprot.org/core/author | "Sun X."xsd:string |
| http://purl.uniprot.org/citations/32139701 | http://purl.uniprot.org/core/author | "Song Q."xsd:string |
| http://purl.uniprot.org/citations/32139701 | http://purl.uniprot.org/core/author | "Sun J."xsd:string |
| http://purl.uniprot.org/citations/32139701 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/32139701 | http://purl.uniprot.org/core/author | "Zhou L."xsd:string |
| http://purl.uniprot.org/citations/32139701 | http://purl.uniprot.org/core/author | "Wang Z."xsd:string |
| http://purl.uniprot.org/citations/32139701 | http://purl.uniprot.org/core/author | "Yang L."xsd:string |
| http://purl.uniprot.org/citations/32139701 | http://purl.uniprot.org/core/author | "Wu X."xsd:string |
| http://purl.uniprot.org/citations/32139701 | http://purl.uniprot.org/core/author | "Cai G."xsd:string |
| http://purl.uniprot.org/citations/32139701 | http://purl.uniprot.org/core/author | "Cai J."xsd:string |
| http://purl.uniprot.org/citations/32139701 | http://purl.uniprot.org/core/author | "Ji Q."xsd:string |
| http://purl.uniprot.org/citations/32139701 | http://purl.uniprot.org/core/author | "Sui H."xsd:string |
| http://purl.uniprot.org/citations/32139701 | http://purl.uniprot.org/core/author | "Feng Y.'"xsd:string |
| http://purl.uniprot.org/citations/32139701 | http://purl.uniprot.org/core/author | "Cai G.'"xsd:string |
| http://purl.uniprot.org/citations/32139701 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32139701 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |