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Background

This study aimed to investigate the clinical application of combined detection of serum calcitonin (Ctn), carcinoembryonic antigen (CEA), and neuron-specific enolase (NSE) in predicting lateral lymph node metastasis (LLNM) in medullary thyroid carcinoma (MTC).

Methods

Seventy-four consecutive patients with MTC were enrolled. The relationship between serum Ctn, CEA, and NSE and LLNM was retrospectively analyzed by univariate analysis and logistic regression analysis. Furthermore, the clinical application of serum Ctn, CEA, and NSE combined detection in prediction of LLNM in MTC was also evaluated.

Results

The rate of LLNM in this study was 48.64% (36/74).The expression levels of serum Ctn, CEA, and NSE in MTC with LLNM were significantly higher than those without LLNM (all P < .01). The area under the curve (AUC) predicted by serum Ctn, CEA, and NSE for LLNM in MTC patients was 0.867, 0.831, and 0.726, respectively, and the AUC of serum Ctn, CEA, and NSE combined detection was up to 0.890, higher than using a single biomarker. The sensitivity and specificity of serum Ctn, CEA, and NSE combined detection in prediction of LLNM were 88.89% and 81.57%, respectively.

Conclusions

The concentrations of serum Ctn, CEA, and NSE are closely related to LLNM in MTC, and the combined detection of all three biomarkers has a higher clinical value in the evaluation of MTC patients with LLNM. With more perspective study in the future, it would be an indicator of influencing personalized surgical strategy for different MTC patients."xsd:string
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http://purl.uniprot.org/citations/32141647http://purl.uniprot.org/core/author"Wang Y."xsd:string
http://purl.uniprot.org/citations/32141647http://purl.uniprot.org/core/author"Zhang J."xsd:string
http://purl.uniprot.org/citations/32141647http://purl.uniprot.org/core/author"Zhou X."xsd:string
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http://purl.uniprot.org/citations/32141647http://purl.uniprot.org/core/author"Ye L."xsd:string
http://purl.uniprot.org/citations/32141647http://purl.uniprot.org/core/date"2020"xsd:gYear
http://purl.uniprot.org/citations/32141647http://purl.uniprot.org/core/name"J Clin Lab Anal"xsd:string
http://purl.uniprot.org/citations/32141647http://purl.uniprot.org/core/pages"e23278"xsd:string
http://purl.uniprot.org/citations/32141647http://purl.uniprot.org/core/title"Combining serum calcitonin, carcinoembryonic antigen, and neuron-specific enolase to predict lateral lymph node metastasis in medullary thyroid carcinoma."xsd:string
http://purl.uniprot.org/citations/32141647http://purl.uniprot.org/core/volume"34"xsd:string
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