| http://purl.uniprot.org/citations/32161266 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32161266 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32161266 | http://www.w3.org/2000/01/rdf-schema#comment | "Major Histocompatibility Complex (MHC) class I molecules selectively bind peptides for presentation to cytotoxic T cells. The peptide-free state of these molecules is not well understood. Here, we characterize a disulfide-stabilized version of the human class I molecule HLA-A*02:01 that is stable in the absence of peptide and can readily exchange cognate peptides. We present X-ray crystal structures of the peptide-free state of HLA-A*02:01, together with structures that have dipeptides bound in the A and F pockets. These structural snapshots reveal that the amino acid side chains lining the binding pockets switch in a coordinated fashion between a peptide-free unlocked state and a peptide-bound locked state. Molecular dynamics simulations suggest that the opening and closing of the F pocket affects peptide ligand conformations in adjacent binding pockets. We propose that peptide binding is co-determined by synergy between the binding pockets of the MHC molecule."xsd:string |
| http://purl.uniprot.org/citations/32161266 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-020-14862-4"xsd:string |
| http://purl.uniprot.org/citations/32161266 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-020-14862-4"xsd:string |
| http://purl.uniprot.org/citations/32161266 | http://purl.uniprot.org/core/author | "Meijers R."xsd:string |
| http://purl.uniprot.org/citations/32161266 | http://purl.uniprot.org/core/author | "Meijers R."xsd:string |
| http://purl.uniprot.org/citations/32161266 | http://purl.uniprot.org/core/author | "Zacharias M."xsd:string |
| http://purl.uniprot.org/citations/32161266 | http://purl.uniprot.org/core/author | "Zacharias M."xsd:string |
| http://purl.uniprot.org/citations/32161266 | http://purl.uniprot.org/core/author | "Hinrichs J."xsd:string |
| http://purl.uniprot.org/citations/32161266 | http://purl.uniprot.org/core/author | "Hinrichs J."xsd:string |
| http://purl.uniprot.org/citations/32161266 | http://purl.uniprot.org/core/author | "Springer S."xsd:string |
| http://purl.uniprot.org/citations/32161266 | http://purl.uniprot.org/core/author | "Springer S."xsd:string |
| http://purl.uniprot.org/citations/32161266 | http://purl.uniprot.org/core/author | "Uetrecht C."xsd:string |
| http://purl.uniprot.org/citations/32161266 | http://purl.uniprot.org/core/author | "Uetrecht C."xsd:string |
| http://purl.uniprot.org/citations/32161266 | http://purl.uniprot.org/core/author | "Anjanappa R."xsd:string |
| http://purl.uniprot.org/citations/32161266 | http://purl.uniprot.org/core/author | "Anjanappa R."xsd:string |
| http://purl.uniprot.org/citations/32161266 | http://purl.uniprot.org/core/author | "Garcia-Alai M."xsd:string |
| http://purl.uniprot.org/citations/32161266 | http://purl.uniprot.org/core/author | "Garcia-Alai M."xsd:string |
| http://purl.uniprot.org/citations/32161266 | http://purl.uniprot.org/core/author | "Aboelmagd M."xsd:string |
| http://purl.uniprot.org/citations/32161266 | http://purl.uniprot.org/core/author | "Aboelmagd M."xsd:string |
| http://purl.uniprot.org/citations/32161266 | http://purl.uniprot.org/core/author | "Kopicki J.D."xsd:string |
| http://purl.uniprot.org/citations/32161266 | http://purl.uniprot.org/core/author | "Kopicki J.D."xsd:string |
| http://purl.uniprot.org/citations/32161266 | http://purl.uniprot.org/core/author | "Lockhauserbaumer J."xsd:string |
| http://purl.uniprot.org/citations/32161266 | http://purl.uniprot.org/core/author | "Lockhauserbaumer J."xsd:string |