| http://purl.uniprot.org/citations/32165585 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32165585 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32165585 | http://www.w3.org/2000/01/rdf-schema#comment | "In neurons, the loading of neurotransmitters into synaptic vesicles uses energy from proton-pumping vesicular- or vacuolar-type adenosine triphosphatases (V-ATPases). These membrane protein complexes possess numerous subunit isoforms, which complicates their analysis. We isolated homogeneous rat brain V-ATPase through its interaction with SidK, a Legionella pneumophila effector protein. Cryo-electron microscopy allowed the construction of an atomic model, defining the enzyme's ATP:proton ratio as 3:10 and revealing a homolog of yeast subunit f in the membrane region, which we tentatively identify as RNAseK. The c ring encloses the transmembrane anchors for cleaved ATP6AP1/Ac45 and ATP6AP2/PRR, the latter of which is the (pro)renin receptor that, in other contexts, is involved in both Wnt signaling and the renin-angiotensin system that regulates blood pressure. This structure shows how ATP6AP1/Ac45 and ATP6AP2/PRR enable assembly of the enzyme's catalytic and membrane regions."xsd:string |
| http://purl.uniprot.org/citations/32165585 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.aaz2924"xsd:string |
| http://purl.uniprot.org/citations/32165585 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.aaz2924"xsd:string |
| http://purl.uniprot.org/citations/32165585 | http://purl.uniprot.org/core/author | "Robinson C.V."xsd:string |
| http://purl.uniprot.org/citations/32165585 | http://purl.uniprot.org/core/author | "Robinson C.V."xsd:string |
| http://purl.uniprot.org/citations/32165585 | http://purl.uniprot.org/core/author | "Wu D."xsd:string |
| http://purl.uniprot.org/citations/32165585 | http://purl.uniprot.org/core/author | "Wu D."xsd:string |
| http://purl.uniprot.org/citations/32165585 | http://purl.uniprot.org/core/author | "Rubinstein J.L."xsd:string |
| http://purl.uniprot.org/citations/32165585 | http://purl.uniprot.org/core/author | "Rubinstein J.L."xsd:string |
| http://purl.uniprot.org/citations/32165585 | http://purl.uniprot.org/core/author | "Bueler S.A."xsd:string |
| http://purl.uniprot.org/citations/32165585 | http://purl.uniprot.org/core/author | "Bueler S.A."xsd:string |
| http://purl.uniprot.org/citations/32165585 | http://purl.uniprot.org/core/author | "Abbas Y.M."xsd:string |
| http://purl.uniprot.org/citations/32165585 | http://purl.uniprot.org/core/author | "Abbas Y.M."xsd:string |
| http://purl.uniprot.org/citations/32165585 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32165585 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32165585 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/32165585 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/32165585 | http://purl.uniprot.org/core/pages | "1240-1246"xsd:string |
| http://purl.uniprot.org/citations/32165585 | http://purl.uniprot.org/core/pages | "1240-1246"xsd:string |
| http://purl.uniprot.org/citations/32165585 | http://purl.uniprot.org/core/title | "Structure of V-ATPase from the mammalian brain."xsd:string |
| http://purl.uniprot.org/citations/32165585 | http://purl.uniprot.org/core/title | "Structure of V-ATPase from the mammalian brain."xsd:string |
| http://purl.uniprot.org/citations/32165585 | http://purl.uniprot.org/core/volume | "367"xsd:string |
| http://purl.uniprot.org/citations/32165585 | http://purl.uniprot.org/core/volume | "367"xsd:string |