| http://purl.uniprot.org/citations/32185508 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32185508 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32185508 | http://www.w3.org/2000/01/rdf-schema#comment | "The free D-amino acid, D-aspartate, is abundant in the embryonic brain but significantly decreases after birth. Besides its intracellular occurrence, D-aspartate is also present at extracellular level and acts as an endogenous agonist for NMDA and mGlu5 receptors. These findings suggest that D-aspartate is a candidate signaling molecule involved in neural development, influencing brain morphology and behaviors at adulthood. To address this issue, we generated a knockin mouse model in which the enzyme regulating D-aspartate catabolism, D-aspartate oxidase (DDO), is expressed starting from the zygotic stage, to enable the removal of D-aspartate in prenatal and postnatal life. In line with our strategy, we found a severe depletion of cerebral D-aspartate levels (up to 95%), since the early stages of mouse prenatal life. Despite the loss of D-aspartate content, Ddo knockin mice are viable, fertile, and show normal gross brain morphology at adulthood. Interestingly, early D-aspartate depletion is associated with a selective increase in the number of parvalbumin-positive interneurons in the prefrontal cortex and also with improved memory performance in Ddo knockin mice. In conclusion, the present data indicate for the first time a biological significance of precocious D-aspartate in regulating mouse brain formation and function at adulthood."xsd:string |
| http://purl.uniprot.org/citations/32185508 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00726-020-02839-y"xsd:string |
| http://purl.uniprot.org/citations/32185508 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00726-020-02839-y"xsd:string |
| http://purl.uniprot.org/citations/32185508 | http://purl.uniprot.org/core/author | "Homma H."xsd:string |
| http://purl.uniprot.org/citations/32185508 | http://purl.uniprot.org/core/author | "Homma H."xsd:string |
| http://purl.uniprot.org/citations/32185508 | http://purl.uniprot.org/core/author | "Katane M."xsd:string |
| http://purl.uniprot.org/citations/32185508 | http://purl.uniprot.org/core/author | "Katane M."xsd:string |
| http://purl.uniprot.org/citations/32185508 | http://purl.uniprot.org/core/author | "Saitoh Y."xsd:string |
| http://purl.uniprot.org/citations/32185508 | http://purl.uniprot.org/core/author | "Saitoh Y."xsd:string |
| http://purl.uniprot.org/citations/32185508 | http://purl.uniprot.org/core/author | "Isidori A.M."xsd:string |
| http://purl.uniprot.org/citations/32185508 | http://purl.uniprot.org/core/author | "Isidori A.M."xsd:string |
| http://purl.uniprot.org/citations/32185508 | http://purl.uniprot.org/core/author | "Caputo V."xsd:string |
| http://purl.uniprot.org/citations/32185508 | http://purl.uniprot.org/core/author | "Caputo V."xsd:string |
| http://purl.uniprot.org/citations/32185508 | http://purl.uniprot.org/core/author | "Di Maio A."xsd:string |
| http://purl.uniprot.org/citations/32185508 | http://purl.uniprot.org/core/author | "Di Maio A."xsd:string |
| http://purl.uniprot.org/citations/32185508 | http://purl.uniprot.org/core/author | "Errico F."xsd:string |
| http://purl.uniprot.org/citations/32185508 | http://purl.uniprot.org/core/author | "Errico F."xsd:string |
| http://purl.uniprot.org/citations/32185508 | http://purl.uniprot.org/core/author | "Usiello A."xsd:string |
| http://purl.uniprot.org/citations/32185508 | http://purl.uniprot.org/core/author | "Usiello A."xsd:string |
| http://purl.uniprot.org/citations/32185508 | http://purl.uniprot.org/core/author | "Falco G."xsd:string |
| http://purl.uniprot.org/citations/32185508 | http://purl.uniprot.org/core/author | "Falco G."xsd:string |
| http://purl.uniprot.org/citations/32185508 | http://purl.uniprot.org/core/author | "De Rosa A."xsd:string |
| http://purl.uniprot.org/citations/32185508 | http://purl.uniprot.org/core/author | "De Rosa A."xsd:string |