| http://purl.uniprot.org/citations/32191225 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32191225 | http://www.w3.org/2000/01/rdf-schema#comment | "SOX2 is a core pluripotency-associated transcription factor causally related to cancer initiation, aggressiveness, and drug resistance by driving the self-renewal and seeding capacity of cancer stem cells (CSC). Here, we tested the ability of the clinically proven inhibitor of the lysine-specific demethylase 1 (LSD1/KDM1A) iadademstat (ORY-100) to target SOX2-driven CSC in breast cancer. Iadademstat blocked CSC-driven mammosphere formation in breast cancer cell lines that are dependent on SOX2 expression to maintain their CSC phenotype. Iadademstat prevented the activation of an LSD1-targeted stemness-specific SOX2 enhancer in CSC-enriched 3-dimensional spheroids. Using high-throughput transcriptional data available from the METABRIC dataset, high expression of SOX2 was significantly more common in luminal-B and HER2-enriched subtypes according to PAM50 classifier and in IntClust1 (high proliferating luminal-B) and IntClust 5 (luminal-B and HER2-amplified) according to integrative clustering. Iadademstat significantly reduced mammospheres formation by CSC-like cells from a multidrug-resistant luminal-B breast cancer patient-derived xenograft but not of those from a treatment-naïve luminal-A patient. Iadademstat reduced the expression of SOX2 in luminal-B but not in luminal-A mammospheres, likely indicating a selective targeting of SOX2-driven CSC. The therapeutic relevance of targeting SOX2-driven breast CSC suggests the potential clinical use of iadademstat as an epigenetic therapy in luminal-B and HER2-positive subtypes."xsd:string |
| http://purl.uniprot.org/citations/32191225 | http://purl.org/dc/terms/identifier | "doi:10.18632/aging.102887"xsd:string |
| http://purl.uniprot.org/citations/32191225 | http://purl.uniprot.org/core/author | "Encinar J.A."xsd:string |
| http://purl.uniprot.org/citations/32191225 | http://purl.uniprot.org/core/author | "Brunet J."xsd:string |
| http://purl.uniprot.org/citations/32191225 | http://purl.uniprot.org/core/author | "Menendez J.A."xsd:string |
| http://purl.uniprot.org/citations/32191225 | http://purl.uniprot.org/core/author | "Alarcon T."xsd:string |
| http://purl.uniprot.org/citations/32191225 | http://purl.uniprot.org/core/author | "Martin A.G."xsd:string |
| http://purl.uniprot.org/citations/32191225 | http://purl.uniprot.org/core/author | "Cuyas E."xsd:string |
| http://purl.uniprot.org/citations/32191225 | http://purl.uniprot.org/core/author | "Martin-Castillo B."xsd:string |
| http://purl.uniprot.org/citations/32191225 | http://purl.uniprot.org/core/author | "Bosch-Barrera J."xsd:string |
| http://purl.uniprot.org/citations/32191225 | http://purl.uniprot.org/core/author | "Verdura S."xsd:string |
| http://purl.uniprot.org/citations/32191225 | http://purl.uniprot.org/core/author | "Gumuzio J."xsd:string |
| http://purl.uniprot.org/citations/32191225 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32191225 | http://purl.uniprot.org/core/name | "Aging (Albany NY)"xsd:string |
| http://purl.uniprot.org/citations/32191225 | http://purl.uniprot.org/core/pages | "4794-4814"xsd:string |
| http://purl.uniprot.org/citations/32191225 | http://purl.uniprot.org/core/title | "The LSD1 inhibitor iadademstat (ORY-1001) targets SOX2-driven breast cancer stem cells: a potential epigenetic therapy in luminal-B and HER2-positive breast cancer subtypes."xsd:string |
| http://purl.uniprot.org/citations/32191225 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/32191225 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32191225 |
| http://purl.uniprot.org/citations/32191225 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32191225 |
| http://purl.uniprot.org/uniprot/#_A0A0B5HFB3-mappedCitation-32191225 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32191225 |
| http://purl.uniprot.org/uniprot/#_A0A0B5HFE5-mappedCitation-32191225 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32191225 |
| http://purl.uniprot.org/uniprot/#_A0A0B5HLA0-mappedCitation-32191225 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32191225 |
| http://purl.uniprot.org/uniprot/#_A8K2R3-mappedCitation-32191225 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32191225 |
| http://purl.uniprot.org/uniprot/#_A0A0B5HP19-mappedCitation-32191225 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32191225 |