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http://purl.uniprot.org/citations/32196589http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/32196589http://www.w3.org/2000/01/rdf-schema#comment"

Objective

We sought to uncover the potential role of long non-coding RNA (lncRNA) ADPGK-AS1 in colorectal cancer (CRC).

Patients and methods

ADPGK-AS1 levels in 58 pairs of CRC tissues and paracancerous tissues and 30 normal colorectal tissues were determined. The in vitro level of ADPGK-AS1 in CRC cell lines was tested as well. The regulatory effects of ADPGK-AS1 on the proliferative, migratory, and invasive properties of HCT116 and SW480 cells were assessed. Using a Dual-Luciferase reporter gene assay, the interaction among ADPGK-AS1/miR-525/FUT1 was identified. Finally, potential influences of the regulatory loop ADPGK-AS1/miR-525/FUT1 on the phenotypes of CRC cells were explored.

Results

ADPGK-AS1 was upregulated in CRC tissues and cells. Knockdown of ADPGK-AS1 attenuated the proliferative, migratory, and invasive abilities of CRC cells. Meanwhile, miR-525 was confirmed to be the target of ADPGK-AS1 and FUT1 was the downstream gene binding miR-525. The regulatory loop ADPGK-AS1/miR-525/FUT1 was found to aggravate the malignant progression of CRC.

Conclusions

ADPGK-AS1 is upregulated in CRC. The regulatory loop ADPGK-AS1/miR-525/FUT1 exacerbates the progression of CRC by promoting the proliferation, migration, and invasion of tumor cells."xsd:string
http://purl.uniprot.org/citations/32196589http://purl.org/dc/terms/identifier"doi:10.26355/eurrev_202003_20505"xsd:string
http://purl.uniprot.org/citations/32196589http://purl.uniprot.org/core/author"Wang Z.J."xsd:string
http://purl.uniprot.org/citations/32196589http://purl.uniprot.org/core/author"Jiang H.Y."xsd:string
http://purl.uniprot.org/citations/32196589http://purl.uniprot.org/core/date"2020"xsd:gYear
http://purl.uniprot.org/citations/32196589http://purl.uniprot.org/core/name"Eur Rev Med Pharmacol Sci"xsd:string
http://purl.uniprot.org/citations/32196589http://purl.uniprot.org/core/pages"2380-2386"xsd:string
http://purl.uniprot.org/citations/32196589http://purl.uniprot.org/core/title"ADPGK-AS1 promotes the progression of colorectal cancer via sponging miR-525 to upregulate FUT1."xsd:string
http://purl.uniprot.org/citations/32196589http://purl.uniprot.org/core/volume"24"xsd:string
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