| http://purl.uniprot.org/citations/32198408 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32198408 | http://www.w3.org/2000/01/rdf-schema#comment | "A direct association has been shown between Cyclin D1 and C-myc gene expressions and the proliferation of human thyroid tumor cells. Our previous study showed that increased β catenin led to a reduction in disease-free probability in patients with papillary thyroid cancer. This study was designed to investigate Cyclin D1 and C-myc genes as targets for β catenin function in PTC and to determine the association between genes expression and staging, recurrence, metastasis, and disease-free survival of PTC. This study was conducted via a thorough investigation of available data from medical records as well as paraffin blocks of 77 out of 400 patients over a 10-year period. Cyclin D1 and C-myc gene expression levels were measured using real-time polymerase chain reaction (RT-PCR) and the Kaplan-Meier method was used to evaluate disease-free survival. Higher levels of Cyclin D1 and C-myc gene expressions were observed in patients with recurrence by 8.5 (P = 0.004) and 19.5 (p = 0.0001) folds, respectively. A significant positive correlation was found between Cyclin D1 expression and the cumulative dose of radioactive iodine received by patients (r = -0.2, p value = 0.03). The ten-year survival rate in the patients included in this study was 98.25% while disease-free survival was 48.1%. Higher Cyclin D1 and C-myc gene expression levels were observed in patients with recurrence/distant metastasis. Inversely, lower expression of Cyclin D1 and C-myc genes were associated with better survival of patients (SD, 0.142-0.052) (Mantel-Cox test, P = 0.002). The enhancement of Cyclin D1 and C-myc gene expression may be a potential mechanism for recurrence and aggressiveness of PTC."xsd:string |
| http://purl.uniprot.org/citations/32198408 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-020-61985-1"xsd:string |
| http://purl.uniprot.org/citations/32198408 | http://purl.uniprot.org/core/author | "Safavi M."xsd:string |
| http://purl.uniprot.org/citations/32198408 | http://purl.uniprot.org/core/author | "Sanjari M."xsd:string |
| http://purl.uniprot.org/citations/32198408 | http://purl.uniprot.org/core/author | "FekriSoofiAbadi M."xsd:string |
| http://purl.uniprot.org/citations/32198408 | http://purl.uniprot.org/core/author | "Ghaseminejad Tafreshi A."xsd:string |
| http://purl.uniprot.org/citations/32198408 | http://purl.uniprot.org/core/author | "Kordestani Z."xsd:string |
| http://purl.uniprot.org/citations/32198408 | http://purl.uniprot.org/core/author | "Mashrouteh M."xsd:string |
| http://purl.uniprot.org/citations/32198408 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32198408 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/32198408 | http://purl.uniprot.org/core/pages | "5100"xsd:string |
| http://purl.uniprot.org/citations/32198408 | http://purl.uniprot.org/core/title | "Enhanced expression of Cyclin D1 and C-myc, a prognostic factor and possible mechanism for recurrence of papillary thyroid carcinoma."xsd:string |
| http://purl.uniprot.org/citations/32198408 | http://purl.uniprot.org/core/volume | "10"xsd:string |
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